摘要
目的观察丙种球蛋白联合地塞米松治疗小儿特发性血小板减少性紫癜的临床疗效。方法将特发性血小板减少性紫癜患儿30例随机分为观察组和对照组各15例。观察组予丙种球蛋白400mg.kg-1.d-1加地塞米松2mg.kg-1.d-1治疗,静脉输注3d后再改用泼尼松2mg.kg-1.d-1口服;对照组不予丙种球蛋白治疗,其余治疗同观察组。观察2组临床疗效、出血症状消失时间、血小板上升时间、血小板恢复时间及住院时间。结果观察组总有效率为93.3%高于对照组的86.7%,差异有统计学意义(P<0.05)。观察组出血症状消失时间、血小板上升时间、血小板恢复正常时间及住院时间均短于对照组,差异均有统计学意义(P<0.05)。结论丙种球蛋白联合地塞米松治疗小儿特发性血小板减少性紫癜疗效显著,值得临床推广使用。
Objective To observe the clinical effect of gamma globulin combined with dexamethasone in children with idiopathic thrombocytopenic purpura.Methods 30 cases children with idiopathic thrombocytopenic purpura were randomly divided into observation group and control group,each of 15 cases.Observation group received intravenous gammaglobulin（400mg·kg^-1·d^-1） combined with dexametrasone（2mg··kg^-1·d^-1）,after 3 days,given oral prednison（2mg··kg^-1·d^-1）.Control group received the same treatment with observation group except gamma globulin.Observed the clinical effect,bleeding symptoms disappear time,platelet rise time,platelet recovery time and hospital stays time of the two groups.Results The total effective rate of observation group（93.3%） was higher than that of control group（86.7%）,the diffenence was syatistically significant（P〈0.05）.Bleeding symptoms disappear time,platelet rise time,platelet recovery time and hospital stays time of observation group were shorter than those of control group,the diffenence were syatistically significant（P〈0.05）.Conclusion The efficacy of gamma globulin combined with dexamethasone in children with idiopathic thrombocytopenic purpura is definite,and worthy of clinical application.
出处
《临床合理用药杂志》
2013年第4期33-34,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
紫癜
血小板减少性
丙种球蛋白
地塞米松
Purpura
idiopathic thrombocytopenic
Gamma globulin
Dexametrasone
