摘要
目的研究预防接种异常反应发生的一般规律,探讨降低反应发生率的方法,客观评价疫苗使用的安全性。方法对2008—2011年天津市和平区疑似预防接种异常反应(AEFI)监测结果进行统计分析。结果 2008—2011年和平区累计报告接种183 459针次,共报告AEFI 42例。各种疫苗总AEFI发生率为22.89/10万。病例主要发生时间为6～9月,以1岁组及以下年龄组为主,其中一般反应27例,异常反应13例,偶合病例2例。麻疹与流行性乙型脑炎疫苗联合免疫AEFI发生率最高,其次为DPT疫苗、白破疫苗。结论该区疫苗使用存在一定程度不安全性,应改良疫苗生产工艺,严格按照操作要求接种,适当减少2种减毒活疫苗联合免疫,加强主动监测。
[Objective]To explore the general rules of adverse events following immunization（AEFI）,to find ways to reduce the AEFI incidence,and objectively evaluate the safety of the vaccine use.[Methods]Statistical analysis was conducted on the AEFI cases in Heping District of Tianjin City from 2008-2011.[Results]A total of 183 459 persons were vaccinated in Heping District of Tianjin City from 2008-2011,with 42 AEFI cases.The total incidence was 22.89/10 000.The cases occurred mainly from June to September.The most were children aged from 8 month-1 year old.There were 27 cases with vaccine general reactions,13 cases with vaccine paradoxical reaction,2 cases with coincidental illness.The highest AEFI incidence was Japanese B Encephalitis vaccine（JEV） combined vaccination with measles vaccine（MV）,followed by the Diphtheria-Pertussis-Tetanus triple vaccine（DPT）and PT.[Conclusion]The vaccine use has a certain degree of insecurity in this district.The quality of vaccines should be improved,injection should be in accordance with the requirements of the operation,2 live attenuated vaccines combined vaccination should be reduced and the active surveillance should be strengthened.
出处
《职业与健康》
CAS
2013年第1期98-100,共3页
Occupation and Health
关键词
预防接种
疫苗
AEFI
监测
Vaccination
Vaccine
Adverse Events Following Immunization（AEFI）
Surveillance
