摘要
目的探讨急性有机磷农药中毒(AOPP)患者三种急性时相反蛋白(APRP):载脂蛋白A1(apoA1)、清蛋白(Alb)、C-反应蛋白(CRP)的检测分析及临床意义。方法 AOPP患者52例(其中,重度中毒12例,中度中毒20例,轻度中毒20例),空腹静脉采血3mL,日产7600型自动生化分析仪免疫比浊法检测血清apoA1、CRP,溴甲酚绿法检测血清Alb。另选取30名门诊健康体检者对照。结果 AOPP患者血清apoA1为(1.08±0.32)g/L、Alb为(38.3±5.1)g/L,较对照组(1.33±0.16)及(44.6±5.4)g/L分别有极显著的降低(P<0.01);CRP(14.22±16.21)mg/L较对照组(2.31±2.11)mg/L有极显著性的升高(P<0.01),且中、重度中毒组三项指标均较轻度中毒组有明显改变(P<0.01),重度中毒组除apoA1外均较中度中毒组有显著性改变(P<0.01),Alb水平进一步下降,CRP升高则更为显著。结论 AOPP时血清apoA1、Alb、CRP改变是全身炎症反应综合征(SIRS)、多脏器损伤的综合表现,观测上述三种APRP的变化,对病情判定、疗效观察均具有重要临床意义。
Objective To investigate the detection and analysis of three kinds of acute-phase reaction protein （APRP） including apolipoprotein A1 （apoA1）, albumin （Alb） and C-reactive protein （CRP） in patients with acute organophosphorus pesticide poisoning （AOPP） and its clinical significance. Methods Fifty two cases of AOPP （including 12 cases of severe poisoning, 20 cases of moderate poisoning and 20 cases of mild poisoning） were included in the study and 3 mL of fasting venous blood were collected from each of them. Sserum apoA1 and CRP of the blood sample were analyzed with immunoturbidimetry assasy using Nissan 7600 automatic biochemical analyzer and serum Alb was analyzed with bromocresol green. 30 cases of outpatients were selected as healthy controls. Results Serum apoA1of （1.08±0.32） g/L and Alb of （38.3±5.1） g/L in AOPP patients were significantly lower than those of （1.33±0.16） and （44.6±5.4） g/L respectively in the control group （P 0.01）; and CRP of （14.22±16.21） mg/L was significantly higher than that of （2.31±2.11） mg/L in the control group （P 0.01）. And in severe poisoning group the three indicators showed significant changes compared with those of mild poisoning group （P 0.01）. Except for apoA1 scores, the indicators of the severe poisoning group also showed significant changes compared with moderate poisoning group （P 0.01）, with further decrease in Alb level and more significant increase of CRP level. Conclusion Changes of apoA1, Alb and CRP levels in AOPP patients are indicative of a systemic inflammatory response syndrome （SIRS） and multiple organ damage. Thus monitoring of the changes of the above three kinds of APRP is important for the diagnosis of the disease and the evaluation of treatment efficacy.
出处
《中国当代医药》
2013年第2期102-103,共2页
China Modern Medicine
关键词
有机磷农药
载脂蛋白A1
清蛋白
C-反应蛋白
Organophosphorus pesticides
Apolipoprotein A1
Albumin
C-reactive protein
