摘要
急性冠状动脉综合征的发生发展与动脉粥样硬化斑块的稳定性密切相关,易损斑块的破裂被认为是急性冠状动脉综合征的主要发病机制。目前研究认为动脉粥样硬化是慢性炎症疾病,越来越多的证据支持炎症反应在动脉粥样硬化的发生发展中起到重要作用。白细胞介素-18是近年来发现的一个促炎细胞因子,其在急性冠状动脉综合征粥样斑块易损性方面发挥了重要作用.并对急性冠状动脉综合征患者的早期诊断和冠状动脉病变的严重程度及对心血管终末事件的发生的预测有重要的临床意义。
The development and occurrence of acute coronary syndrome is closely related to the stability of the atheroselerotic plaque. The rupture of vulnerable plaques was thought to be the main pathogenesis of acute coronal7 syndrome, however, current research proposes that atherosclerosis is a chronic inflammatory disease. Evidence has shown inflammation plays a key role in the occurrenee and development of atherosclerosis. Interleukin-18 has been found to promote pro-inflammatory cytokine, and plays an important role in atherosclerotic plaque vulnerability. Interleukin-18 has clinical significance in predicting an early diagnosis, and the severity of the coronary disease and cardiovas- cular terminal events in patients with acute coronary syndrome.
出处
《心血管病学进展》
CAS
2013年第1期118-120,共3页
Advances in Cardiovascular Diseases
