摘要
目的观察重度妊娠高血压疾病(HCDP)对早产儿血液系统的影响。方法回顾性分析北京大学第一医院新生儿重症监护室2008年1月至2011年6月收治的先兆子痫和子痫母亲之早产儿75例(观察组),以同期收治的健康母亲之早产儿60例作为对照组,比较两组的血常规特点、变化及影响因素,以及早产儿常见相关并发症的差异。结果观察组出生体重和胎龄小于对照组,小于胎龄儿(SGA)较对照组多(P<0.01)。观察组生后6h内、2～3d及5～7d白细胞计数(WBC)、中性粒细胞绝对计数(ANC)及血小板计数(BPC)均低于对照组(P<0.01),其中WBC及ANC减少以生后6h内最多见(42.7%),BPC减少以生后2～3d最多见(49.3%)。BPC减少与患儿性别及母亲BPC状态无关(P>0.05),而与低出生体重和SGA有关(P<0.01)。观察组感染率高于对照组(P<0.01),其他常见相关并发症两组间差异无统计学意义(P<0.01)。结论重度HCDP可引起早产儿生后BPC减少和ANC减少,与低出生体重和SGA有关,临床易发生感染。
Objective To observe the effects of severe maternal hypertensive disorder complicating pregnancy on pre- term infant hematological system. Methods Seventy-five cases of preterm infants of pre-eclampsia or eclampsia moth- ers, hospitalized from Jan. 2008 to dun. 2011 in Department of Pediatrics, Peking University First Hospital were studied retrospectively, controlled to 60 cases of preterm infants of healthy mother at the same time. The results and changes of blood routine test were compared between two groups, as well as its influencing factor. Results The mean birth weight and gestational age were lower while the percentage of small gestational age was higher in observation group than in con- trol group （P 〈 0.01 ）. The mean values of white blood cell count, absolute neutrophil count and blood platelet count were much lower, while the cases of neutropenia and thrombocytopenia were more common in observation group than in con- trol group （P 〈 0.01 ）. Neutropenia was found mostly within 6 hours after birth at 42.7%, while thrombocytopenia was found mostly at 2 to 3 clays after birth at 49.3%. It was not sex or mother platelet number but low birth weight and small gestational age that had influence on thrombocytopenia （P 〈 0.01 ）. Preternl infants of observation group had much high- er infection rate than the control group （P 〈 0.01 ）. Conclusion Preterm infants of severe maternal hypertensive disor- der complicating pregnancy might have neutropenia and thrombocytopenia related to low birth weight and small gestation- al age, and are more apt to be infected.
出处
《中国实用儿科杂志》
CSCD
北大核心
2013年第1期48-51,共4页
Chinese Journal of Practical Pediatrics
