摘要
目的:探讨乳洁安中丹参的主要活性成分丹参素的药物动力学。方法:家兔口服给予乳洁安流浸膏,在不同时间点采集血样,用HPLC法测定丹参素血药浓度的经时变化,以3P87药动学软件进行分析,计算药动学参数。结果:家兔血浆中药动学参数分别为:ka为(5.5±1.2)h-1,k为(0.95±0.18)h-1,t1/2为(0.75±0.12)h,Cmax为(5.3±0.6)μg.mL-1,tmax为(0.40±0.06)h,AUC0-t为(6.3±1.2)μg.h.mL-1,AUC0-∞为(7.0±1.3)μg.h.mL-1。结论:乳洁安中丹参素进入兔体内后分布快,药物起效迅速,本研究为乳洁安的进一步开发提供了有价值的药动学数据。
OBJECTIVE To study the pharmacokinetics of Danshensu the chief active component in Rujiean. METHODS HPLC was used to determine Danshensu concentration in rabbits＇ serum at different time-points after oral administration. The pharmacokinetic parameter were calculated by 3P87. RESULTS The main pharmacokinetic parameters were as follows：ka （5. 5 ± 1.2）h -1 ,k（0. 95 ± 0. 18）h-1 ,t1/2 （0. 75 ± 0. 12）h,Cmax （5.3 ± 0. 6）μg·mL-1, tmax （0. 40 ± 0. 06）h, AUC0-t （6. 3 ± 1. 2）μg·h·mL-1 , AUC0-∞ （7. 0 ± 1.3） μg·h·mL-1. CONCLUSION The pharmacokinetics of Danshensu showed a rapid distribution and effect. The present research provided valuable data for advanced development of Rujiean.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2013年第3期179-181,共3页
Chinese Journal of Hospital Pharmacy
基金
湖北省科技攻关计划项目(编号:2004AA301C49)
湖北省卫生厅科研基金项目项目(编号:JX3B53)
