摘要
目的探讨慢性肾功能衰竭(CRF)的常见病因并分析其病因变化,为指导CRF的病因诊断和正确防治提供依据。方法回顾性分析2006年9月至2011年12月在中国医科大学附属第四医院住院、门诊、血液净化中心透析、腹膜透析的937例患者的CRF病因,了解其病因特点。结果 CRF患者的病因构成前5位依次为慢性肾小球肾炎(26.15%)、糖尿病肾病(25.51%)、慢性间质性肾炎(19.64%)、高血压肾损害(14.41%)和梗阻性肾病(5.23%)。不同年龄段及不同慢性肾脏病(CKD)分期CRF病因构成有差别。本研究显示,60岁以上以及CKD 3期、4期的CRF患者,糖尿病肾病为首要病因,所占比例分别为26.54%和27.57%。而59岁以下及CKD 5期的CRF患者,慢性肾小球肾炎仍为首要病因,所占比例分别为43.06%和29.84%。结论本研究显示,慢性肾小球肾炎虽仍为CRF的首要病因,但糖尿病肾病所占比例已与之非常接近,且60岁以上以及CKD 3期和4期的CRF患者,糖尿病肾病已成为首要病因。其次分别为慢性间质性肾炎,高血压肾损害,慢性梗阻性肾病等。
Objective To investigate the common etiologies and their differences in patients with chronic renal failure （CRF） , thus allowing for guidance of the prevention and treatment. Methods We did a retrospective review on the etiolo- gies of CRF in 937 adults who were treated with hemodialysis and peritoneal dialysis in the in-patient or out-patient clinics, Fourth Affiliated Hospital of China Medical University, between January 2006 and December 2010, for determination of the etiologic features. Results The five leading etiologies of CRF were as follows：chronic glomerulonephritis （26. 15% ） , dia- betic nephropathy （ 25.51% ）, chronic interstitial nephritis （ 19.64% ） , hypertensive renal impairment （ 14.41% ） and ob- structive nephropathy （5.23%）. The distribution of etiologies varied considerably in different age groups and CKD stages. Our resuhs showed that diabetic nephropathy was the leading cause of CRF in patients aged over 60 years and those at sta- ges CKD3/CKD4 （26. 54% and 27.57% , respectively）. Whereas chronic glomerulonephritis was the most common etiology of CRF in patients aged less than 59 years and those at stage CKD5 （43.06% and 29. 84% ,respectively）. Conclusion Chronic glomerulonephritis retains its first ranking in the etiology yet incidence of diabetic nephropathy is approaching. In patients with CRF aged over 60 years and those at stages CKD3/CKD4, diabetic nephropathy has become the leading etiolo- gy, followed by interstitial nephritis, hypertensive renal impairment and chronic obstructive nephropathy.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2013年第1期58-61,共4页
Chinese Journal of Practical Internal Medicine
关键词
病因
慢性肾功能衰竭
终末期肾衰竭
慢性肾小球肾炎
糖尿病肾病
慢性间质性肾炎
高血压肾损害
pathogeny
chronic renal failure
end stage renal failure
chronic glomerulo-nephritis
diabetic nephropathy
chro-nic interstitial nephritis
hyper-tensive renal impairment
