摘要
目的:观察石榴皮提取物对链脲佐菌素诱导小鼠糖尿病的预防作用。方法:KM小鼠灌胃石榴皮乙酸乙酯提取物(Pomegranate Acetic ether Extract,PAE)3周后连续4次小剂量腹腔注射链脲佐菌素(STZ)诱导小鼠糖尿病,尾静脉取血测血糖,放免法检测血清胰岛素水平,制备石蜡切片光学显微镜观察胰腺组织病理学变化。结果:30 mg/kg PAE预防给药能对抗STZ引起的胰岛面积萎缩、空泡变,促进胰岛素分泌,显著对抗STZ诱导的血糖升高。结论:石榴皮乙酸乙酯提取物能预防STZ诱发的小鼠糖尿病。
To observe the preventive effects of pomegranate peel extract（PAE） on streptozotocin induced diabetes in mice. Methods： Repeated small dose streptozotocin was introperitoneally given to KM mice after PAE was lavaged for three weeks. The blood glucose was de- tected by blood glucose monitor,blood insulin level was determined by radioimmunoassay, and pathological change of pancreatic tissue was ob- served by optical microscope. Results： PAE can improve STZ induced atrophy and vacuolar degeneration in mouse pancreatic island, promote insulin secretion,has obviously antihyperglycemic effects on STZ induced diabetes. Conclusion： Pomegranate peel extract can prevent STZ induced diabetes in mice on a certain degree.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2012年第6期96-98,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
新疆维吾尔自治区自然科学基金(2012211A038)
新疆医科大学药理学重点学科青年启动基金
关键词
石榴皮
血糖
胰岛素
胰脏病理
Pomegranate peel blood glucose
insulin
pancreas pathology change
