摘要
目的探讨亚高原地区急性心肌梗死(AMI)患者体液免疫变化及其临床意义。方法 52例AMI患者(AMI组)分别在胸痛发作6h以内、72h、7d、15d、21d、30d检测血清IgG、IgA、IgM水平并与50例健康对照组进行对比分析。结果 AMI组胸痛发作6h以内血清IgG、IgA、IgM水平与健康对照组比较差异无统计学意义(P>0.05);胸痛发作72h血清IgG、IgA、IgM水平开始升高;胸痛发作第7天,血清IgG、IgA水平明显升高,与健康对照组比较差异有统计学意义(P<0.01),且持续升高至15d;第21天血清IgG、IgA水平开始下降,30d后血清IgG、IgA基本恢复正常水平,与健康对照组比较差异无统计学意义(P>0.05)。结论亚高原地区AMI患者早期免疫功能处于抑制状态,体液免疫功能紊乱,持续时间长。AMI患者免疫功能变化与病情转归有密切关系,动态观察免疫球蛋白含量变化,可作为AMI病情观察的动态指标。
Objective To explore the humoral immune changes and its clinical significance in the patients with acute myocardial infarction（AMI） in the sub-plateau region.Methods The serum IgG,IgA and IgM levels was examined in 52 cases of acute myocardial infarction（AMI group） patients within 6h,at 72 h,on 7 day,15 day,21 day and 30 day after chest pain onset and compared with 50 cases of healthy subjects（control group） in the sub-plateau region.Results The serum IgG,IgA and IgM levels showed no significant change within 6 h of onset of chest pain in patients with AMI chest pain as compared with those of healthy control group,but with a declining trend.The serum IgG,IgA and IgM levels began to rise at 72 h after the onset of chest pain.The serum IgG and IgA levels was significantly increased 7 days,continued to increase until 15 days,began to decline 21 days and returned to normal levels 30 day later afer chest pain onset as compared with those of healthy control.Conclusion The early immune function is in an inhibitory state and exists a humoral immune dysfunction in patients with AMI in sub-plateau region.This immune function exchange is with a long duration and closely related to the disease outcome.Dynamic observation of changes in the serum immunoglobulin content can be observed as the dynamic indicators of the AMI condition.
出处
《国际检验医学杂志》
CAS
2012年第24期2980-2981,共2页
International Journal of Laboratory Medicine
关键词
高海拔
心肌梗死
抗体生成
altitude
myocardial infarction
antibody formation
