摘要
目的 :研究古拉定 (还原型谷胱甘肽 )防治头颈部肿瘤放疗所致口腔粘膜、放射反应的临床效果及不良反应。方法 :从放疗第 3周起 ,随机分为治疗组 (古拉定 ) 4 0例及对照组 (口泰 ) 39例 ,按WHO粘膜反应 0～ 4级标准 ,观察口腔粘膜反应及药物不良反应。结果 :第 4周两组疗效对比无明显差异 (P >0 .0 5 ) ,第 7周古拉定组3～ 4级反应明显少于口泰组 ,差异显著 (P <0 .0 5 ) ,无明显药物不良反应。结论
Objective:To study the effect of gluthion in prevention of mucitis induced by radiotherapy.Methods:79 patients who are receiving radiotherapy were divided to receive gluthion( n =40) or Koutai( n =39) to prevent mucitis induced by radiotherapy.The mucosal reactions were classified into 4 degrees according to WHO's standard.Results:No significant differences between groups were observed until the seventh weeks.At 7 weeks mucitis in gluthion group was much fewer than that of the Koutai group.No side effects were observed in both groups.Conclusion:Gluthion is a valuable adjuvant for prevention of mucitis in patients with head and neck carcinnama receiving radiotherapy.
出处
《中国新药杂志》
CAS
CSCD
2000年第7期473-474,共2页
Chinese Journal of New Drugs
