摘要
目的系统评价改良Hodge试验(MHT)检测产碳青霉烯酶肠杆菌科细菌的准确性。方法计算机检索PubMed、中国生物医学文献数据库等数据库(CBM),收集用MHT检测产碳青霉烯酶肠杆菌科细菌的实验研究,依据QUADAS质量评价标准评价纳入研究的质量后,进行Meta分析。结果共纳入8个研究,合计1254份无重复标本。Meta分析显示:MHT检测产碳青霉烯酶肠杆菌科细菌的合并敏感度、特异度、阳性似然比、阴性似然比、诊断比值比和SROC曲线下面积分别为0.96、0.94、10.01、0.06、168.98和0.989。结论 MHT对于产碳青霉烯酶肠杆菌科细菌的表型检测具有很高的敏感度、特异度和准确性。
Objective To evaluate the accuracy of Modified Hodge Test（MHT） for carbapenemase-producing Enterobacteriace- ae. Methods Systematic and comprehensive literature was searched in PubMed,The Cochrane Library, CBM, CNKI,Weipu tech- nology periodical database and Wanfang database, the diagnosis studies of MHT for carbapenemase-producing Enterobacteriaceae were included. The quality assessment of diagnostic accuracy studies（QUADAS）items were used to assess the quality of the includ- ed studies. The Meta software was used to analyze the data. Results A total of 8 trials involving 1 254 bacterial strains with out re- peat were included. The results of meta-analyses showed that compared with the PCR,the summary sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, OR value,and summary receiver operating characteristic curve of MHT for the detection of carbapenemase-producing Enterobacteriaceae were 0. 96,0.94,10.01,0.06,168.98 and 0. 989 respectively. Conclusion MHT is one of the most efeetive diagnoses for arbapenemase-producing Enterobacteriaceae.
出处
《国际检验医学杂志》
CAS
2012年第22期2710-2711,共2页
International Journal of Laboratory Medicine
