摘要
目的探讨肝病患者凝血功能检测指标与病情的关系。方法分别检测338例不同类型肝病患者和54例健康体检对照者的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)水平,用SPSS17.0统计软件对各项指标进行组间t检验分析,同时对肝硬化患者的凝血功能和肝功能Child-Push分级进行相关性分析。结果急性肝炎组PT显著延长(P<0.01),慢性轻度肝炎进展为慢性中、重度肝炎时PT、APTT、TT显著延长(P<0.05或P<0.01),FIB合成显著减少(P<0.05或P<0.01);肝硬化患者凝血功能与肝功能Child-Push分级从A、B到C级的进展之间呈负相关。结论从肝功能正常到肝炎-肝硬化的过程中,随着患者肝细胞受损程度不断加重,PT、APTT、TT逐渐延长,而FIB水平则逐渐下降;PT、APTT、TT、FIB的检测对评价肝脏受损程度、了解肝病患者不同病程时期的凝血功能状况及患者预后评估等均具有重要意义。
Objective To Explore the correlation between the patients＇ condition and a number of coagulation test results in pa- tients with various liver diseases. Methods 338 patients with various liver diseases and 54 healthy control were detected for PT, APTT,TT and FIB levels. SPSS17.0 was employed for t test and the Correlation Analysis between the coagulation function and Child-Push grading in patients with cirrhosis for liver function. Results PT in acute hepatitis group was significantly prolonged （P〈0.01）, and with the progression of mild and moderate chronic hepatitis to severe hepatitis,PT, APTT and TT levels were sig- nificantly prolonged（P〈0.05 或 P〈0.01）, while FIB synthesis was significantly reduced（P〈0.05 或 P〈0.01 ） ;A negative corre- lation was noticed between the blood coagulation function and I.iver function classification of the Child Push development from A, B to C in patients with cirrhosis. Conclusion With the development of liver disease from hepatitis to cirrhosis,the liver function was becoming worse with increasing liver cell damage, and a positive correlation between the levels of patient PT, APTT,TT and liver damage was found, while FIB level was found to be negatively correlated with liver damage;PT, APTT, TT and FIB tests were valuable for evaluating the degree of liver damage in patients with liver disease, understanding the different coagulation status during the course of the disease,and also for the evaluation of prognosis.
出处
《国际检验医学杂志》
CAS
2012年第21期2587-2589,共3页
International Journal of Laboratory Medicine
