摘要
目的分析库欣病患者经蝶手术治疗前后代谢特征的变化。方法对2003年1月至2010年12月在我院行经蝶手术治疗的50例患者的临床资料进行回顾性分析。结果术前:54%患者体重指数(BMI)>25,86%患者血脂异常,80%患者患高血压,20%患者有糖尿病,BMI大于>25的患者血脂异常(96.3%)及脂肪肝(51.9%)的发生率较高(P<0.05);术后:患者BMI、收缩压(SBP)及舒张压(DBP)均较术前明显下降(P<0.01);51.9%BMI>25的患者于术后6个月之内降至25kg/m2以下,平均恢复时间为(4.1±1.6)个月;92.5%的高血压患者在随访期间血压恢复正常,平均恢复时间(3.9±7.3)个月。结论库欣病应早期行经蝶手术治疗;术后患者高血压、糖及脂代谢异常有不同程度的缓解,但仍有较高的发生心血管事件的风险。
Objective To analyze the metabolic changes of patients with Cushingg disease before and after transsphenoidal surgery. Methods Clinical data of 50 patients underwent transsphenoidal surgery between January 2003 and December 2010 in Tongji Hospital were analyzed retropectively. Results Pre-operation： body mass index （BMI） 〉25 was detected in 54% patients, abnormal blood lipid in 86% patients, hypertension in 80% and diabetes mellitus in 20%. Abnormal blood lipid （96.3%） and fatty liver （51.9%） were more common in patients with BMI 〉 25 （P 〈0. 05）. Post-operation： BMI, systolic blood pressure （SBP） and diastolic blood pressure （DBP） were decreased obviously （P 〈0. 01 ）. BMI of 51.9% patients （ BMI 〉 25） was decreased to normal level less than 6 months after surgery, with 4. 1 ± 1.6 months in average. The blood pressure of 92. 5% patients with hypertension recovered during the follow-up, with 3.9 ± 7.3 months in average. Conclusion Transsphenoidal surgery should be performed in patients with Cushing＇s disease at early stage. Hypertension and the abnormality of glucose and lipid metabolism are relieved to some extent, but a higher risk of cardiovascular disease should be paid attention to.
出处
《中华神经外科疾病研究杂志》
CAS
2012年第6期530-534,共5页
Chinese Journal of Neurosurgical Disease Research
关键词
库欣病
经蝶手术
代谢变化
Cushings disease
Transsphenoidal surgery
Metabolic changes
