摘要
目的观察矽尘接触者、矽肺患者及尘肺观察对象血清白介素-8(IL-8)和血小板衍生生长因子-AA(PDGF-AA)水平,探讨IL-8和PDGF-AA在矽肺发生、发展中的作用。方法选择110名不接触粉尘的对照人群(对照组)、211名接触矽尘1年以上的接尘工人(接尘组)、48名矽尘作业观察对象(0+)(观察对象组)及155例矽肺患者(矽肺组),采用ELISA法检测其血清IL-8和PDGF-AA水平。结果 IL-8水平:与对照组[(6.55±1.94)ng.L-1]比较,接尘组、观察对象组和矽肺组IL-8[(49.66±5.42)、(111.07±10.08)、(226.45±19.03)ng.L-1]明显升高(P<0.01);与接尘组比较,观察对象组和矽肺组明显升高(P<0.05或P<0.01)。PDGF-AA水平:与对照组[(26.38±10.14)ng.L-1]和接尘组[(27.31±12.22)ng.L-1]比较,观察对象组和矽肺组[(56.26±14.35)、(65.16±11.94)ng.L-1]明显升高(P<0.05或P<0.01)。结论 IL-8和PDGF-AA在矽肺发生、发展中有重要作用,检测外周血IL-8和PDGF-AA水平有利于职业健康监护及矽肺的早期诊断。
Objective To observe serum interleukin-8（IL-8） and platelet-derived growth factor-AA（PDGF-AA） levels in silicosis patients and workers exposed to silica dust,and to study the roles of IL-8 and PDGF-AA in the occurrence and development of silicosis.Methods Serum IL-8 and PDGF-AA levels were determined by ELISA in 110 workers not exposed to dust（control group）,211 workers exposed to silica dust for more than l year（exposed group）,48 patients with suspected silicosis（origi-nally diagnosed as 0＋,observation group）,and l55 silicosis patients（silicosis group）.Results Serum IL-8 levels in exposed group[（49.66±5.42）ng·L-1],observation group[（111.07±10.08） ngoL-1]and silicosis group[（226.45±19.03）ng·L-1]were significantly higher than those in control group[（6.55±1.94）ng·L-1]（P0.01）.Compared with exposed group,serum IL-8 levels obviously increased in silicosis group and observation group（P0.05 or P0.01）.In addition,serum PDGF-AA levels in obs-ervation group[（56.26±14.35）ng·L-1]and silicosis group[（65.16±11.94）ng·L-1]significantly increased,compared with control group[（26.38±10.14）ng·L-1] and exposed group[（27.31±12.22）ng·L-1]（P0.05 or P0.01）.Conclusion IL-8 and PDGF-AA were essential in the occurrence and development of silicosis.The detection of IL-8 and PDGF-AA in peripheral blood was very useful for occupational health surveillance and early diagnosis of silicosis.
出处
《实用临床医学（江西）》
CAS
2012年第12期19-21,共3页
Practical Clinical Medicine
