摘要
目的：比较玻璃体腔注射不同剂量曲安奈德（TA）治疗黄斑水肿（DME）的疗效及安全性。方法：经临床确诊为DME者34例34眼，按就诊的先后时间分组，分别注射TA4mg和2mg，每组各17例17眼。在患眼颞下象限角巩膜缘后4mm处行玻璃体腔注射。术后1、4、8、12周观察并比较2组患眼的视力、眼压及并发症的情况。结果：所有患者视力在治疗后4个时间点与各自注射前视力相比差异均有统计学意义，2mg组术后4周、8周视力改善明显，12周时视力出现回退，但与治疗前比较差异有统计学意义（P=0．000），4mg组注射后4个时间点视力相互比较差异均有统计学意义。2mg组与4mg组间治疗后各时间点视力均提高，但注射后各时间点的比较差异均无统计学意义。两组4个时间点上的眼压值与术前比较，4周与8周比较，8周与12周比较差异均无统计学意义。但4mg组在治疗后4～8周有3例眼压〉21mmHg（17．6％），12周后眼压均在正常范围。2mg组未发生眼压升高病例。2组间治疗后眼压比较：4周（t=-2．48，P=0．015）；8周（t=-2．90，P=-0．004）；12周（t=-3．02，P=0．003）差异均有统计学意义。结论：玻璃体腔注射曲安奈德（TA）治疗黄斑水肿（DME）的疗效肯定，低剂量TA安全性更好。
Objective： To compare the curative effect and security of treating patients with cystoid macular edema（CME） by intravitreal injecting different dose triamcinolone acetonide（TA）. Methods： 34 eyes of 34 patients with CME were divided into two guoups according to visiting time（each 17 eyes of 17 patients） in which TA 4mg and 2mg were injected respectively to each eyes（intravitreal injection： 4mm ＇after corneoscleral junction in the inferotemporal quadrant of affected eye）. Visual acuity, intraocular pressure and complications were compared in two groups after 1,4,8 and 12 weeks. Results ： There was statistical significance of all patients before and after treatment at 4 point in time in which visual acuity was obvious improvement after treatment at 4,8 weeks in 2mg group, but vist, al acuity was rollback after treatment at 12 weeks in 2mg group. There was statistical significance in visual acuity after treatment at 4 point of 4mg group. Visual acuity was average improvement after treatment at 4 point in time in two groups,but there was no statistical significance among different point in time. There was statistical significance in intraocular pressure after treatment at 4,8 weeks of two groups,and there was statistical significance in intraocular pressure after treatment at 8,12 weeks of two groups. There were 3 cases whose intraocalar pressure were 〉21mmHg （17.6%）at 4-8 week,and other were normal range in 4rag group. Intraocular pressure of all patients was normal range after treatment in 2mg group. There was statistical significance in intraocular pressure after treatment between two guoups at 4 week （t=-2A8,P=0.015）,8 week （t=-2.90, P=0.004）, 12week （t=-3.02,P=0.003）. Conclusion： Intravitreal injecting triamcinolone acetonide is definite curative effect and good safety of small dose TA for patients with CME.
出处
《甘肃医药》
2013年第2期87-90,共4页
Gansu Medical Journal
关键词
曲安奈德
黄斑水肿
玻璃体注射
triamcinolone acetonide
cystoid macular edema
intravitreal injection
