miRNA在糖尿病肾病发病中的意义及其检测手段
被引量:2
摘要
糖尿病肾病(DN)是糖尿病的严重的并发症之一,细胞外基质(ECM)蛋白的积聚、肾小球系膜细胞的增生和肥大、肾小球足细胞功能障碍等是DN的主要病变特点。随着糖尿病患者日趋增多,调查发现DN已成为导致我国终末期肾病的重要原因。
出处
《中国实验诊断学》
2013年第1期190-193,共4页
Chinese Journal of Laboratory Diagnosis
基金
吉林大学科学前沿与交叉学科创新项目
吉林大学研究生创新基金资助项目(20121123)
吉林大学"大学生创新创业训练计划"项目(2012B71216)
参考文献16
-
1CarringtonJ C,Ambros V. Role of microRNAs in plant and ani-mal development [J] . Science,2003,301 (5631) :336. 被引量:1
-
2Hammond S M . microRNA detection comes of age. Nat Meth-ods, 2006 ,3 : (1) : 12. 被引量:1
-
3张政,罗勇军,彭惠民,何晓燕.早期糖尿病肾病相关微小RNA在小鼠肾脏的表达变化[J].第三军医大学学报,2010,32(13):1383-1386. 被引量:7
-
4ZhangZ, Peng H, Chen J , et al. MicroRNA-21 protects fromme-sangial cell proliferation induced by diabetic nephropathy in db/db mice [J] . FEBS Lett,2009,583(12) :2009. 被引量:1
-
5MicroRNA-451 regulates p38 MAPK signaling by targeting ofYwhaz and suppresses the mesangial hypertrophy in early diabet-ic nephropathy. 2012,586(1) :20. 被引量:1
-
6WangQ, Wang Y,Minto AW.et al. MicroRNA -377 is upregulat-ed and can lead to increased fibronectin production in diabetic ne-phropathy [J] . FASEBJ,2008,22C12):4126. 被引量:1
-
7KatoM,Zhang J,Wang M,et al. MicroRNA -192 in diabetic kid-ney glomeruli and its function in TGF-beta-induced collagen ex-pression via inhibition of E-box repressors. Proc Natl Acad SciUSA,2007,104(9):3432. 被引量:1
-
8KatoM, Putta S, Wang M, et al. TGF - J3 activates Akt kinasethrough a microRNA dependent amplifying circuit targetingPTEN[J] . Nat Cell Biol,2009,11(7) :881. 被引量:1
-
9KrupaA, Jenkins R, Luo DD, et al. Loss of microRNA-192 pro-motes fibrogenesis in diabetic nephropathy. J Am Soc Nephrol,2010,21(3):438. 被引量:1
-
10WarkA W,Lee H J,Corn R M. Multiplexed detection methodsfor profiling microRNA expression in biological samples[J] . An-gew Chem Int Ed,2008,47(4) :644. 被引量:1
二级参考文献16
-
1Collins A J, Foley R N, Herzog C, et al. United States Renal Data System 2008 Annual Data Report Abstract [ J]. Am J Kidney Dis, 2009, 53(1 Suppl) : VI-VII, S8 -S374. 被引量:1
-
2Poy M N, Eliasson L, Krutzfeldt J, et al. A pancreatic islet-specific microRNA regulates insulin secretion [ J ]. Nature, 2004, 432 (7014 ) : 226 - 230. 被引量:1
-
3Xiao J, Luo X, Lin H, et al. MicroRNA miR-133 represses HERG K^+ channel expression contributing to QT prolongation in diabetic hearts[ J]. J Biol Chem, 2007, 282(17) : 12363 -12367. 被引量:1
-
4Makino H, Miyamoto Y, Sawai K, et al. Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone [ J ]. Diabetes, 2006, 55 (10) : 2747 - 2756. 被引量:1
-
5Livak K J, Schmittgen T D. Analysis of relative gene expression data using real-time quantitative PCR and the 2( -Delta Delta C(T) ) Method[J]. Methods, 2001, 25(4): 402-408. 被引量:1
-
6Lim A K, Ma F Y, Nikolic-Paterson D J, et al. Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice [J]. Diabetologia, 2009, 52 (8) : 1669 -1679. 被引量:1
-
7Sayyed S G, Hagele H, Kulkarni O P, et al. Podocytes produce home ostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes [ J ]. Diabetologia, 2009, 52 ( 11) : 2445 - 2454. 被引量:1
-
8Mima A, Arai H, Matsubara T, et al. Urinary Smadl is a novel marker to predict later onset of mesangial matrix expansion in diabetic nephropathy[J]. Diabetes, 2008, 57(6) : 1712 - 1722. 被引量:1
-
9Lee R C, Feinbaum R L, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin- 14[J]. Cell, 1993, 75(5): 843-854. 被引量:1
-
10Lewis B P, Burge C B, Bartel D P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets[J]. Cell, 2005, 120( 1 ) : 15 -20. 被引量:1
共引文献6
-
1鲁琼,李焕德.miRNA在糖尿病血管并发症中的研究进展[J].中南药学,2012,10(3):212-215. 被引量:1
-
2彭睿,周吉,李天驹,孙艳,尹频,彭惠民,张政.miR-451调控早期糖尿病肾病小鼠肾小球肥大的机制[J].重庆医科大学学报,2014,39(11):1584-1589.
-
3邵晓娜,耿嘉男,胡彦武,刘凯,石艳.microRNA与糖尿病肾病关系的探讨[J].中国实验诊断学,2015,19(11):1974-1977. 被引量:3
-
4孙成博,孙波,刘春禹,李星儒,王志琴,张璟祎,张雪绵,王泽红,于晓艳.茵陈提取物对糖尿病大鼠肾组织中miRNAs表达谱的影响及其肾脏保护作用[J].吉林大学学报(医学版),2018,44(3):493-498. 被引量:9
-
5郭钦,白洁,何宇轩,唐川惠,操庆国,董英.天然产物与microRNA调控代谢综合征的研究进展[J].食品科学,2017,38(9):239-247. 被引量:2
-
6鲁冰,任东升,王松.三种微小RNA在糖尿病肾脏疾病肾纤维化患者中的水平变化及临床应用研究[J].中国糖尿病杂志,2019,27(3):189-193. 被引量:16
同被引文献24
-
1Yukinari Yamaguchi,Masayuki Iwano,Daisuke Suzuki,Kimihiko Nakatani,Kuniko Kimura,Koji Harada,Atsushi Kubo,Yasuhiro Akai,Masao Toyoda,Masao Kanauchi,Eric G. Neilson,Yoshihiko Saito.Epithelial-Mesenchymal Transition as a Potential Explanation for Podocyte Depletion in Diabetic Nephropathy[J].American Journal of Kidney Diseases.2009(4) 被引量:1
-
2Bartel DP. MicroRNAs: target recognition and regulatory func- tions[J]. Cell, 2009,136(2): 215. 被引量:1
-
3Kim VN. MicroRNA biogenesis: coordinated cropping and dicing [J]. Nat Rev Mol Cell Biol,2005,6(5) :376. 被引量:1
-
4Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs:are the answers in sight[J]. Nat Rev Genet,2008,9(2) :102. 被引量:1
-
5Takahashi P, Xavier DJ, Evangelista AF, et al. MicroRNA ex- pression profiling and functional annotation analysis of their tar- gets in patients with type 1 diabetes mellitus[J]. Gene, 2014,539 (2):213. 被引量:1
-
6Hezova R,Slaby O, Faltejskova P, et al. MicroRNA-342, microR- NA-191 and microRNA-510 are differentially expressed in T reg- ulatory cells of type 1 diabetic patients[J].2010,260(2) : 70. 被引量:1
-
7Salas-Perez F, Codner E, Valencla E, et al. MicroRNAs mir-21aand miR-93 are down regulated in peripheral blood mononuclear cells (PBMCs) from patients with type 1 diabetes[J]. 2013,218 (5):733. 被引量:1
-
8Nielsen LB, Wang C, Bang-Berthelsen CH, et al. Circulating lev- els of microRNA from children with newly diagnosed type 1 dia- betes and healthy controls;evidence that miR-25 associates to re- sidual beta-cell function and glycaemic control during disease progression[J]. Exp Diabetes Res, 2012,2012 : 896362. 被引量:1
-
9Rome S. Are extracellular microRNAs involved in type 2 diabetes and related pathologies [J]? Clin Biochem, 2013, 46 ( 10-11 ) : 937. 被引量:1
-
10Zhang T,Lv C, Li L, et al. Plasma miR-126 is a potential bio- marker for early prediction of type 2 diabetes mellitus in suscep- tible individuals[J]. Biomed Res Int, 2013,2013 : 761617. 被引量:1
二级引证文献4
-
1梁品传.多靶点治疗老年肾病综合征的临床疗效观察[J].临床合理用药杂志,2018,11(10):26-27.
-
2兰天,刘巍梦,邹阳,邱平.MicroRNA-21表达与糖尿病肾病相关性研究[J].华南预防医学,2019,45(4):376-378. 被引量:5
-
3雷震坤.甲泼尼龙联合雷公藤多甙治疗老年肾病综合征的临床观察[J].世界最新医学信息文摘,2016,16(7):115-116. 被引量:2
-
4崔明春.肾病综合征患者血浆脂联素和单核细胞趋化蛋白-1的关系[J].世界最新医学信息文摘,2017,0(51):59-59.
-
1木合台尔江.吐尔迪.甘精胰岛素联合格列美脲治疗2型糖尿病50例分析[J].新疆医学,2008,38(12):88-89. 被引量:1
-
2联合用药有助提升糖化血红蛋白达标率[J].医药前沿,2015,0(8):3-3.
-
3崔巧丽,隋志芳,王银霞,朱铁虹.神经生长因子对胰淀素所致大鼠胰岛细胞功能障碍的保护作用[J].天津医药,2010,38(5):409-411. 被引量:2
-
4陈璐璐.脂代谢紊乱与β细胞凋亡[J].国外医学(内分泌学分册),2005,25(3):156-158. 被引量:6
-
5汤志梅,张建梅,王煜,邬云红,李洁,赵铁耘,冉兴无,童南伟,高勇义,李秀钧.胰岛素抵抗大鼠胰岛内胰淀素表达对β细胞凋亡的影响及干预研究[J].中华内分泌代谢杂志,2007,23(5). 被引量:1
-
6冯玉英,郭涛.辛伐他汀对原发性高血压患者颈动脉内-中膜厚度的影响[J].中国伤残医学,2009,17(6):87-88.
-
7王子威,陈莹.MicroRNA与系统性红斑狼疮发病机制研究进展[J].实用医学杂志,2017,33(7):1057-1060. 被引量:10
-
8夏小明.遗传,内环境因素与高血压病的血管平滑肌细胞功能障碍[J].临床心血管病杂志,1990,6(4):246-248.
-
9李华.治疗2型糖尿病的新力量——GLP-1类似物利拉鲁肽[J].求医问药(下半月刊),2012,10(6):197-198. 被引量:9
-
10于乐成.人血清白蛋白、全身炎症反应与肝硬化[J].肝脏,2015,20(2):153-156. 被引量:10