摘要
目的通过分析Survivin蛋白在正常子宫内膜、子宫内膜增生症(包括单纯性增生和复杂性增生子宫内膜组织)、不典型增生子宫内膜和子宫内膜癌中的表达及其在子宫内膜腺癌不同临床病理分期、分级中的表达,探讨Survivin在从正常子宫内膜向子宫内膜样腺癌转变过程中作用及与子宫内膜癌临床病理分期、组织学分级的关系。方法采用免疫组化S-P法对正常子宫内膜组织20例、子宫内膜增生症组织20例、不典型增生子宫内膜组织20例、子宫内膜腺癌组织40例,进行Survivin蛋白的检测并分析。结果1.Survivin蛋白的表达率:在正常子宫内膜组和子宫内膜增生症组中Survivin蛋白表达均明显低于于不典型增生子宫内膜组和子宫内膜癌组中Survivin蛋白表达(P<0.05),正常子宫内膜组和子宫内膜增生症组之间表达无差异性。2.Survivin蛋白在子宫内膜癌不同组织学分级组(高分化G1、中分化G2,低分化G3)、不同手术病理分期组表达无明显统计学意义(P>0.05)。结论Survivin蛋白的表达降低在正常子宫内膜向内膜样腺癌的转变中起重要作用;其低表达与子宫内膜样腺癌的病理分期、组织学分级无明显相关性。
Objective Through the analysis of the expressions of the Survivin in different endometrial tissue and in different clinical-pathology stages and histologic grade of endometrial adenocarcinoma,to explore the actions of Survivin in the development of the endometrial adenocarcinoma and in different clinical-pathology stages and histologic grade of endometrial adenocarcinoma. Methods Using S-P method to detect and analyse the expression of Survivin in 20 cases of normal endometrial organizations,20 cases of endometrial hyperplasia,20 cases of atypical endometrial,and 40 cases of endometrial adenocarcinoma. Results 1. the expression rate of Survivin：the expression of Survivin in group normal en dometrial and endometrial hyperplasia were significantly lower than in the group atypical endometrial and adenocarcino ma （P〈 0. 05）, between normal endometrial and endometrial hyperplasia, atypical endometrial and adenocareinoma, there were no difference（P〉0.05）. 2. the expression of Survivin in different histological grade （well-differentiatedG1, middle differentiatedG2, low differentiatedG3）, and in different clinical-pathology stages there were no statistically difference（P〉0.05）. Conclusion the low expression of Survivin have a significant effective in the development of en- dometrial adenocarcinoma, but have no significant effective in different clinical-pathology stages and histologic grade of endometrial adenocarcinoma.
出处
《中国实验诊断学》
2013年第1期88-90,共3页
Chinese Journal of Laboratory Diagnosis
