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睾丸鞘膜恶性间皮瘤3例临床病理分析及文献复习 被引量:2

Malignant mesothelioma of the tunica vaginalis testis:a clinicopathological observation of 3 cases and review of the literatures
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摘要 目的探讨睾丸鞘膜恶性间皮瘤(malignant mesothelioma)的临床病理学特征及诊断、鉴别诊断要点。方法对3例睾丸鞘膜恶性间皮瘤进行临床病理学分析、免疫组化EnVision两步法染色及超微结构观察,并结合文献对该病的临床表现、组织形态学特点、免疫表型、超微结构特点和预后进行探讨。结果 3例患者临床症状均为阴囊肿块伴或不伴鞘膜积液,大体观察肿瘤呈结节状,直径0.4~5.0 cm,切面实性或囊实性,灰白,质韧。光镜下见肿瘤细胞形态多样,呈巢状、束状、编织状、实性片状或腺管状排列,瘤细胞胞质空淡或淡红染,核圆形、卵圆形或不规则形,核仁明显,核分裂象可见。免疫表型:瘤细胞均表达CKpan、Calretinin、EMA、vimentin、calponin、CK7、Villin;部分表达CK5/6、WT-1、CEA、SMA、S-100蛋白、CD34、CEA;D2-40、HBME-1、CD30、desmin、CD117和CK20均阴性;Ki-67增殖指数10%~30%。电镜观察细胞表面可见多量细长的微绒毛,细胞间可见细胞间连接,包括桥粒和连接复合体,胞质内见多量细胞丝,包括张力原纤维及一定数量的糖原。结论睾丸鞘膜恶性间皮瘤较罕见,临床诊断较困难。确诊需根据其光镜病理形态特征,辅以免疫组化标记和(或)电镜检查。病理学上应与间皮增生、腺瘤样瘤、睾丸网腺癌、浆液性乳头状肿瘤等鉴别。该肿瘤完全切除后预后较好,以随访为主,可行放、化疗等辅助治疗。 Purpose To study the clinicopathological features of malignant mesothelioma (MM) of the tunica vaginalis testis and pro- vide useful imformation for the diagnosis and differential diagnosis of the tumor. Methods The morphology features of 3 malignant mesotheliomas of the tunica vaginalis testis were observed by gross observation, HE staining and electron microscopy. Immunohisto- chemisty was used to identify the immunophenotype. We also reviewed the literatures to further analyze the clinical manifestations, his- topathologieal features, immunohistochemisty, treatment and prognosis of MM. Results The three cases presented with scrotal masses with or without hydroeele. Macroseopically, the tumors are nodular, 0. 4 - 5.0 cm in diameter. On the cut surface, the tumors are sol- id or cystic-solid, gray-white and texture tough. Microscopically, tumor cells arranged in varied patterns: nested, faseicular, storiform, solid sheets and glandular. Cytoplasm is pale or light. Nucleus is round, oval or irregular in shape, with prominent nucleoli, and mi- totic figures can be seen. Immunohistochemically, the tumor cells expressed CKpan, Calretinin, EMA, vimentin, ealponin, CK7 and Villin. Some of the tumor cells expressed CK5/6, WT-1, CEA, SMA, S-100, CD34 and CEA. While D2-40, HBME-1, CD30, desmin, CD117 and CK20 were negative. Proliferation index was 10% -30%. By electron microscope, there were a lot of elongated microvilli on tumor cells surface. Intercellular junctions were also observed between tumor cells, including desmosome and junctional complex. There were a lot of cytofilaments in the cytoplasma, including tonofilaments and a certain amount of glycogen. Conehlsions Malignant mesothelioma of the tuniea vaginalis testis is rare, and it can be difficult to diagnosis clinically. The definite diagnosis re- quires light microscopy plus immunohistology and (or) electron microscopy. The differential diagnosis including mesothelial hyperplasi- a, adenomatoid tumor, adenocarcinoma of the fete testis, and papillary
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2013年第1期40-44,共5页 Chinese Journal of Clinical and Experimental Pathology
关键词 恶性间皮瘤 睾丸鞘膜 鉴别诊断 超微结构 malignant mesotheliom tunica vaginalis testis differential diagnosis ultrastructure
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参考文献13

  • 1Chekol S S,Sun C C. Malignant mesothelioma of the tunica vaginalis testis:diagnostic studies and differential diagnosis[J].Archives of Pathology and Laboratory Medicine,2012,(01):113-117. 被引量:1
  • 2Ikegami Y,Kawai N,Tozawa K. Malignant mesothelioma of the tunica vaginalis testis related to recent asbestos[J].International Journal of Urology,2008,(06):560-561. 被引量:1
  • 3Fujimoto N,Aoe K,Gemba K. Clinical investigation of malignant mesothelioma in Japan[J].Journal of Cancer Research and Clinical Oncology,2010,(11):1755-1759. 被引量:1
  • 4黄彩虹,李家驭,丁志燕,刘爽,俞国祥.睾丸鞘膜恶性间皮瘤1例[J].诊断病理学杂志,2010,17(4):316-317. 被引量:5
  • 5Goel A,Agrawal A,Gupta R. Malignant mesothelioma of the tunica vaginalis of the testis without exposure to asbestos[J].Cases J,2008,(01):310. 被引量:1
  • 6Murai Y. Malignant mesothelioma in Japan:analysis of registered autopsy cases[J].Archives of Environmental Health,2011,(01):84-88. 被引量:1
  • 7Chen J L,Hsu Y H. Malignant mesothelioma of the tunica vaginalis testis:a case report and literature review[J].Kaohsiung Journal of Medical Sciences,2009,(02):77-81. 被引量:1
  • 8Al-Salam S,Hammad FT,Salman M A. Expressiom of Wilms tumor-1 protein and CD138 in malignant mesothelioma of the tuniva vaginalis[J].Pathology Research and Practice,2009,(11):797-800. 被引量:1
  • 9Wang M T,Mak C W,Tzeng W S. Malignant mesothelioma of the tunica vaginalis testis:unusual sonographic appearance[J].Journal of Clinical Ultrasound,2005,(08):418-420.doi:10.1002/jcu.20140. 被引量:1
  • 10Winstanley A M,Landon G,Berney D. The immunohistochemical profile of malignant mesotheliomas of the tunica vaginalis:a study of 20 cases[J].American Journal of Surgical Pathology,2006,(01):1-6. 被引量:1

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同被引文献20

  • 1朱正龙,吴佩红,叶琴,石群立,孟丹.睾丸鞘膜高分化乳头状间皮瘤一例及文献复习[J].江苏医药,2004,30(12):941-942. 被引量:4
  • 2Bonetti LR, Schirosi L, Sartori G, et al. Well-differentiated papillary mesothelioma of the epididymis in a man with recurrent haematospermia[ J]. Andrologia ,2012,44 (4) :285 - 287. 被引量:1
  • 3Fukunaga M. Well-differentiated papillary mesothelioma of the tunica vaginalis : a case report with aspirate cytologic, irmnunohistochemical, and uhrastructural studies [ J ].Pathol Res Pract,2010,206(2) : 105 - 109. 被引量:1
  • 4Chen X, Sheng W, Wang J. Well-differentiated papillary mesotheliorna: a clinieopathological and immunohistochemical study of 18 cases with additional observation [ J ]. Histopathology, 2013,62(5) :805 -813.. 被引量:1
  • 5Trpkov K, Barr R, Kulaga A, et al. Mesothelioma of tunica vaginalis of " uncertain malignant potential " --an evolving concept: case report and review of the literature [ J ]. Diagn Patho1,2011,25 ( 6 ) :78. 被引量:1
  • 6Gurel B,Ali TZ,Montgnmery EA, et al. NKX3.1 as a marker of prostatic origin in metastatic tumors [ J ]. Am J Surg Pathol, 2010,34(8) :1097 - 1105. 被引量:1
  • 7Sheridan T, Herawi M, Epstein Jl, et al. The role of P501S and PSA in the diagnosis of metastatic adenocareinoma of the prostate [J]. Am J Surg Pathol, 2007,31 (9) :1351 - 1355. 被引量:1
  • 8Hyun TS, Barnes M, Tabatabai ZL. The diagnostic utility of D2- 40, calretinin, CK5/6, desmin and MOC-31 in the differentiation of mesothelioma from adenocarcinoma in pleural effusion cytology[ J]. Aeta Cyto1,2012,56(5 ) :527 - 532. 被引量:1
  • 9Ord6fiez NG. Value of podoplanin as an immunohistochemieal marker in tumor diagnosis: a review and update [ J ]. Appl Immunohistochem Mol Morpho1,2014 ,22 ( 5 ) :331 - 347. 被引量:1
  • 10Kuperman M, Florence RR, Pantanowitz L, et al. Distinguishing benign from malignant mesothelial cells in effusions by Glut-l, EMA, and desmin expression: an evidence based approach [ J ]. Diag Cytopatho1,2013,41 (2) : 131 - 140. 被引量:1

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