摘要
肺癌是严重影响人类健康的恶性肿瘤之一，影响肺癌发病的表观遗传学机制已成为近年来的研究热点。慢性阻塞性肺病（chronicobstructivepulmonarydisease，COPD）不但是肺癌的常见合并症，而且可能是肺癌的独立风险因素。肺癌和COPD在表观遗传学水平的改变主要涉及DNA甲基化、组蛋白修饰和非编码RNA调控等。探讨肺癌与COPD在表观遗传学水平的改变及其相互关系，可为肺癌及COPD的发病机制、疾病进展、疾病预后等提供更为广阔的视角，并为疾病的治疗开辟新的方向。
Lung cancer and chronic obstructive pulmonary disease （COPD） are the leading causes of morbidity and mortality worldwide. Development of lung cancer involves both genetic and environment factors. In addition to genetic alterations, epigenetic mechanism is closely involved in pathogenesis of lung cancer. Characterized by an abnormal persistent inflammatory response to noxious environmental stimulation, COPD has shown to increase the susceptibility for lung tumorigenesis in previous research. Current research on epigenetics of lung cancer and COPD has focused on aberrant DNA methylation, histone acetylation and non-coding RNAs regulation. The aberrant DNA methylation associated with lung cancer and COPD has included overexpression of DNA methyltransferase, global DNA hypomethylation and DNA hypermethylation in promoter regions, while histone acetylation and histone methylation are the major changes for histone modification, in which histone acetyltransferases, histone deacetylases, histone methyltransferases and histone demethylases play the most important roles. RNA interference and microRNAs are both hot topics of research on non-coding RNAs regulation. Understanding of concurrent epigenetic alterations in the pathogenesis of lung cancer and COPD may facilitate identification of specific therapeutic targets and development of effective treatment.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
2013年第1期70-73,共4页
Chinese Journal of Medical Genetics
基金
国家自然科学基金项目（81072257）
