摘要
目的:探讨慢性丙型肝炎患者红细胞CR1黏附活性与血清TGF-β1水平的相关性。方法:采用红细胞天然免疫功能试验和酶联法对32例慢性丙型肝炎患者进行了红细胞CR1黏附活性测定和血清TGF-β1测定,并与35名正常健康人作比较。结果:慢性丙型肝炎患者红细胞CR1黏附活性显著地低于正常人组(P<0.01),血清TGF-β1水平非常显著地高于正常人组(P<0.01),红细胞CR1黏附活性的变化与TGF-β1水平相关。结论:慢性丙型肝炎患者红细胞CR1黏附活性与TGF-β1水平相关,对判断病情的轻重、发生和发展具有一定的临床价值。
Objective To explore the correlativity between changes of adheremce activity of erythrocyte CR1 and serum TGF-β1 levels in patients with chronic hepatic C. Methods Erythrocyte CR1 adherence activity was detected with erythrocyte immune function test and serum TGF-β1 level with ELISA in 32 patients with chronic hepatic C and compared to 35 normal healthy controls. Results The erythrocyte CR1 adherence activity in patients with chronic hepatic C showed significantly lower than that controls （ P 〈 0.01 ）, While the serum TGF-β1 level was markedly higher than that in controls（P 〈0.01 ）. The change of CR1 adherence activity was closely correlated with the change of serum TGF-β1 level. Conclusion Change of erythrocyte CR1 adherence activity was closely correlated with the serum TGF-β1. Also, provides certain clinical value to predict the severity of pathosis, pathogeny and development.
出处
《放射免疫学杂志》
CAS
2013年第1期80-81,共2页
Journal of Radioimmanology
关键词
慢性丙型肝炎
红细胞
受体
补体
转化生长因子-Β1
chronic hepatic C, erythrocyte, receptor, complement, transforming growth factor-β1 （TGF-β1）
