摘要
目的:观察补阳还五汤对偏头痛患者血浆降钙素基因相关肽(CGRP)和内皮素(ET)的影响。方法:72例偏头痛患者随机分为两组,西药组36例,口服尼莫地平20～40 mg,每日3次;急性发作期加服麦角胺咖啡因片1～2片/次。中药组36例,给予补阳还五汤,每日1剂,水煎分早晚服。两组均连续治疗3个月。治疗前、后监测偏头痛发作频率、持续时间、严重程度、药物的不良反应、CGRP和ET的水平,并与36例正常人对照。结果:中药组的总有效率显著高于西药组(P<0.05);两组偏头痛患者均较正常人ET明显增高(均P<0.01),CGRP明显降低(均P<0.01);西药组和中药组均可降低ET水平、偏头痛积分,提高CGRP水平(均P<0.01),但中药组比西药组作用更明显(均P<0.01)。服用补阳还五汤未发生明显的不良的反应。结论:补阳还五汤能通过调节血管活性物质CGRP,ET水平,改善血管的异常舒缩状况,从而达到缓解偏头痛的作用。
Objective： To observe the influence of Buyang Huanwu decoction on endothelin （ET） and calcitonin gene-related peptide （CGRP） in patients with migraine. Method： Seventy two patients with migraine were divided into 2 groups randomly, 36 patients in western medicine group were treated by Nimodipine tablets 20- 40 mg once, 3 times a day, To add ergotamine caffeine 1-2 tablets once in acute seizure phase. 36 patients in Chinese medicine group were treated by Buyang Huanwu decoction, take a decoction a day, divided into morning and evening. Patients had received continuous treatment for three months. Migraine frequency, duration, severity, adverse drug reactions and the concentration of plasma CGRP and ET were monitored before and after treatment. And comparative study with 36 cases of normal. Result： The total efficiency of traditional Chinese medicine group was significantly higher than that of the western medicine group （P 〈 0.05） ; ET in patients with migraine was significantly higher than those of normal people （ all P 〈 0.01 ） , CGRP in patients with migraine was significantly lower than those of normal people （all P 〈 0.01 ）; ET concentration, migraine scores were significantly lower and CGRP concentration were significantly increased patients than before treatment （ all P 〈 0.01） ; However, the role of traditional Chinese medicine group is more obvious than the western medicine group （all P 〈 0.01 ）; Buyang Huanwu decoction has no significant adverse reactions. Conclusion： Buyang Huanwu decoction eliminate migraine by regulate vasoactive substances CGRP, ET level and improve the condition of abnormal systolic and diastolic blood vessels.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第2期311-314,共4页
Chinese Journal of Experimental Traditional Medical Formulae
