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秀丽隐杆线虫在毒理学研究中的应用进展 被引量:5

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摘要 近年来模式生物秀丽隐杆线虫(Caenorhabditiselegans,简称线虫或C.elegans)被应用于生命科学的许多领域,在信号转导、细胞分化、衰老、细胞凋亡、热应激反应、性别决定、神经肌肉发育、神经分化诱导、行为认知、药物筛选、生态毒理及神经毒理等方面。已经取得了突破性的研究成果。线虫具有饲养条件简单、廉价和易操作的等特点。线虫成虫体长1mm,身体半透明,以大肠杆菌为食饵,在自然状态下线虫是一种可以自我繁殖的雌雄同体生物,繁殖迅速,从受精卵发育到成虫仅需不到四天时间。
出处 《毒理学杂志》 CAS CSCD 北大核心 2012年第6期466-469,共4页 Journal of Toxicology
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  • 1Leung MC, Williams PL, Benedetto A, et al. Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology[J]. Toxicol Sci. 2008, 106( 1 ) :5-28. 被引量:1
  • 2Chen BL, Hall DH, Chklovskii DB. Wiring optimization can relate neuronal structure and function [ J]. Proc. Natl Acad. Sci. USA. 2006,103 (12) ,4723-4728. 被引量:1
  • 3Anderson GL, Cole RD, Williams PL. Assessing behavioral toxicity with Caenorhabditis elegans [ J ]. Environ. Toxicol. Chem. 2004,23 (5) :1235-1240. 被引量:1
  • 4Wang S, Tang M, Pei B, et al. Cadmium-induced germline apoptosis in Caenorhabditis elegans: The roles of HUS1, p53, and MAPK signaling pathways [ J ]. Toxicol. Sci. 2008,102(2) : 345-351. 被引量:1
  • 5Sambongi Y, Nagae T, Liu Y, et al. Sensing of cadmium and copper ions by externally exposed ADL, ASE, and ASH neurons elicits avoidance response in Caenorhabditis elegans[ J]. Neuroreport. 1999,10(4) :753-757. 被引量:1
  • 6Hilliard MA, Apicella AJ, Kerr R, et al. In vivo imaging of C. elegans ASH neurons: Cellular response and adaptationto chemical repellents [ J ]. E MBO J. 2005,24 ( 1 ) :63-72. 被引量:1
  • 7Mori I, Sasakura H, Kuhara A. Worm thermotaxis: A model system for analyzing thermosensation and neural plasticity [ J ]. Curr. Opin. Neurobiol. 2007,17 ( 6 ) :712-719. 被引量:1
  • 8Jiang GC, Tidwell K, McLaughlin BA, et al. Neurotoxic potential of depleted uranium effects in primary cortical neuron cultures and in Caenorhabditis elegans [ J ]. Toxicol. Sci. 2007,99(2) :553-565. 被引量:1
  • 9Clejan I, Boerckel J, Ahmed S. Developmental modulation of nonhomologous end joining in Caenorhabditis elegans [J]. Genetics. 2006,173(3) : 1301-1317. 被引量:1
  • 10Holway AH, Kim SH, La Volpe A, et al. Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos [ J]. J. Cell Biol. 2006, 172(7) : 999-1008. 被引量:1

同被引文献99

  • 1秦峰松,杨崇林.小线虫,大发现:Caenorhabditis elegans在生命科学研究中的重要贡献[J].生命科学,2006,18(5):419-424. 被引量:30
  • 2周秀艳,王艳,韩桂春.工业废水生物毒性监测与综合评价[J].辽宁工程技术大学学报(自然科学版),2007,26(2):293-295. 被引量:8
  • 3中华人民共和国卫生部.GB15193-2003.食品安全性毒理学评价程序和方法[S].北京:中国标准出版社,2004:87-88. 被引量:6
  • 4周宗灿,付立杰.现代毒理学简明教程[M].北京:军事医学科学出版社,2012:92-93. 被引量:4
  • 5Leung M C K, Williams P L, Benedetto A, et al. Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology [ J ]. Toxieol Sei, 2008,106 ( 1 ) : 5-28. 被引量:1
  • 6Brenner S. The genetics of Caenorhabditis elegans [ J ]. Genetics, 1974,77 ( 1 ) :71-94. 被引量:1
  • 7LI Y, GAO S,JING H M, et al. Correlation of chemical acute toxicity between the nematode and the rodent [ J ]. Toxicol Res, 2013,2:403-412. 被引量:1
  • 8OECD. Guidance document on using cytotoxicity tests to estimate starting doses for acute oral systematic toxicity tests [ Z/OL ]. 2010 ( 2013-03 -01 ) [ 2014-02-11 ]. http ://www. oecd. org/env/ehs/ testing/seriesontestingandassessmenttestingforhumanheahh, htm. 被引量:1
  • 9Vanduyn N, Settivari R, WONG G, et al. SKN-1/NrI2 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of methylmercury toxicity[J]. Toxicol Sci,2010,118(2) :613-624. 被引量:1
  • 10WU Q,QU Y, L1 X, et al. Chromium exhibits adverse effects at environmental relevant concentrations in chronic toxicity assay system of nematode Caenorhabditis elegans chemosphere [ J ]. 2012,87(11) :1281-1287. 被引量:1

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