摘要
目的观察帕金森病（PD）患者和特发性震颤（ET）患者抑郁的发生情况及与其相关的因素。方法收集2010年8月至2011年6月苏州大学附属第二医院PD门诊确诊为PD的患者121例，2009年7月至2010年6月苏州大学附属第二医院门诊临床诊断为ET的患者62例。对PD患者进行H-Y分期和统-PD评定量表（UPDRS）-UI评分。对ET患者进行震颤评定量表（TRS）-PartA、PartB评分。汉密尔顿抑郁量表（HAMD，24项版本）评定患者的抑郁程度。结果121例PD患者中抑郁发生率为56．2％，62例ET患者中抑郁发生率为53．2％，两组轻度抑郁发生率为38．9％和35．5％、中度抑郁发生率为15．7％和17．7％、重度抑郁发生率为1．7％和O％，差异均无统计学意义（均P〉0．05）。PD组与ET组HAMD各因子比较显示两组认知障碍得分为（1．81±1．86）分和（1．04±1．07）分，绝望感得分为（2．95±1．97）分和（4．09±2．08）分，差异有统计学意义（P〈0．05），而两组焦虑／躯体化、体重减轻、Et夜变化、阻滞及睡眠障碍差异无统计学意义（P〉0．05）。PD患者中，抑郁与UPDRS-IU评分显著相关（r=0．511，P〈0．01）；ET患者中，抑郁与TRS（PartA＋PartB）评分显著相关（r=0．828，P〈0．01）。结论运动障碍疾病常见的两个疾病PD和ET中抑郁有较高发生率，两者的抑郁程度相似，抑郁症状主要表现为焦虑、心境恶劣、工作和兴趣减退、迟缓、失眠等。抑郁与运动障碍在症状呈正相关。和PD患者的非运动症状相似，ET患者的非运动症状也同样值得关注。
Objective To explore the incidence of depression in movement disorders and associated factors. Methods A total of 121 Parkinson＇s disease （PD） patients from August 2010 to June 2011 and 62 ET patients from July 2009 to June 2010 were recruited. All of them were outpatients of our hospital. PD patients received the unified Parkinson＇s disease rating scale （UPDRS） -motor examination and a modified Hoehn and Yahr scale to stage the severity of their disorders while 62 essential tremor （ET） patients were evaluated with tremor rating scale for tremor-motor examination （ items t-15 of rating scale）. All participants completed Hamilton depression rating scale （24 items） to measure the presence and degree of symptoms of depression. Results It was found that 56.2% of PD patients and 53.2% of ET patients were depressed （HAMD score of 8 or higher）. Among them, the rates of mild depression were 38.9% and 35.5% , moderate depression 15.7% and 17.7% and severe depression 1.7% and 0% in PD and ET patients respectively. No significant differences existed between each group. The factor scores of cognitive impairment were 1.81 ± 1.86 and 1.04 ± l. 07 in PD and ET patients while those of sense of despair were 2.95± 1.97 and 4.09 ± 2.08 in each group. The differences had statistical significance in two factor scores of two groups （P 〈 0.05 ）. No differences in anxiety/somatization, lose weight, day-and-night changes, block and sleep disorders between two groups. For PD patients, the motor score of UPDRS - HI was positively correlated with total HAMD score （r =0. 511 ,P 〈0.01 ）. Similarly, for ET patients, tremor rating scale for tremor-motor subscale score and HAMD score were positively correlated （ r = 0. 828, P 〈 0.01 ）. Conclusion As two common movement disorders, PD and ET have a high incidence of depression. The severity of depression is similar in two groups. There is no significant intra-group difference in severity and frequency of depression. The most common symptoms are anx
出处
《中华医学杂志》
CAS
CSCD
北大核心
2013年第1期26-29,共4页
National Medical Journal of China
关键词
帕金森病
特发性震颤
抑郁
Parkinson disease
Essential tremor
Depression
