期刊文献+

先天性巨结肠术后并发小肠结肠炎的危险因素分析 被引量:11

Analysis of the Risk Factors of Enterocolitis after Surgery of Hirschsprungs Disease
下载PDF
导出
摘要 [目的]探讨先天性巨结肠术后并发小肠结肠炎的危险因素。[方法]选取湖南省儿童医院2009年1月1日至2010年12月31日期间在新生儿外科住院的年龄3个月内经手术治疗的先天性巨结肠惠儿98例。采用单因素logistic回归和多因素logistic回归统计分析术后并发小肠结肠炎的危险因素。[结果]98例患儿中,男78例(79.6%);女20例(20.4%)。治愈96例(98%);死亡2例(2%)。20例(20.4%)术后发生小肠结肠炎,单因素logistic回归分析表明,并发小肠结肠炎的危险因素主要是营养不良、肠梗阻、牛奶过敏、肺炎、肠神经节细胞减少和败血症。多因素logistic回归分析表明,其危险因素主要是营养不良、肠梗阻、肠神经节细胞减少和肺炎。[结论]小肠结肠炎是先天性巨结肠术后常见而且严重的并发症,营养不良、肠梗阻、肠神经节细胞减少和肺炎可能是术后小肠结肠炎的独立危险因素。改善患儿营养状况,解除肠梗阻因素和保护肠道黏膜可减少该并发症的发生。 [Objective] To explore the risk factors of enterocolitis after surgery of Hirschsprung's disease. [Methods] A total of 98 pediatric patients with Hirschsprung's disease undergoing the operation within 3 months in neonate surgery department of children's hospital of Hunan province from Jan. 2009 to Dec. 2010 were chosen. Univariate logistic regression and multifactor logistic regression analysis were used to analyze the risk factors of enterocolitis after operation. [Results] Among 98 pediatric patients, 78 patients(79.6%) were male and 20 patients(20.40//oo) were female. The 96 patients(98%) were cured, and 2 patients(2%) died. The 20 patients(20.4%) were complicated with enterocolitis after operation. Univariate logistic regression analysis showed that the main risk lactors of complicated enterocolitis were malnutrition, intestinal obstruction, milk allergy, pneumonia, hypoganglionosis and septicemia. Multifactor logistic regression analysis showed that the risk factors were malnutrition, intestinal obstruction, hypoganglionosis and pneumonia. [Conclusion] Entero- colitis is the common and serious complication for Hirschsprung's disease after operation. Malnutrition, intesti- nal obstruction, hypoganglionosis and pneumonia may be the independent risk factors of enterocolitis after operation. Improving nutrition, removing intestinal obstruction and protecting mucous membrane of pediatric patients can reduce the incidence of the complication.
出处 《医学临床研究》 CAS 2012年第12期2325-2327,共3页 Journal of Clinical Research
关键词 HIRSCHSPRUNG病 外科学 手术后并发症 小肠结肠炎 病因学 危险因素 Hirschsprung disease/SU postoperative complications enterocolitis/ET risk factors
  • 相关文献

参考文献10

  • 1Bill AH,Chapman ND. The enterocolitis of Hirschsprung's disease:Its natural history and treatment[J].American Surgeon,1962,(01):70-73. 被引量:1
  • 2Elhalaby EA,Coran AG,Blane CE. Enterocolitis associated with Hirschsprung's disease:A clinical-radiological characterization based on 168 patients[J].Journal of Pediatric Surgery,1995,(01):76-83. 被引量:1
  • 3Menezes M,Puri P. Long-term outcome of patients with enterocolitis complicating Hirschsprung's disease[J].Pediatric Surgery International,2006,(04):316-318. 被引量:1
  • 4Estevao-Costa J,Fragoso AC,Campos M. An approach to minimize postoperative enterocolitis in Hirschsprung's disease[J].Journal of Pediatric Surgery,2006,(10):1704-1707. 被引量:1
  • 5Suzuki T,Won KJ,Horiguchi K. Muscularis inflammation and the loss of interstitial cells of Cajal in the endothelin ETB receptor null rat[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2004,(03):638-646. 被引量:1
  • 6Haricharan RN,Seo JM,Kelly DR. Older age at diagnosis of Hirschsprung disease decreases risk of postoperative enterocolitis,but resection of additional ganglionated bowel does not[J].Journal of Pediatric Surgery,2008,(06):1115-1123.doi:10.1016/j.jpedsurg.2008.02.039. 被引量:1
  • 7Hackam DJ,Filler RM,Pearl RH. Enterocolitis after the surgical treatment of Hirschsprung's disease:Risk factors and financial impact[J].Journal of Pediatric Surgery,1998,(06):830-833. 被引量:1
  • 8汤绍涛,周欣,阮庆兰,郭筱兰,刘春萍,毛永忠,王勇.先天性巨结肠术后发生小肠结肠炎的高危因素[J].中华小儿外科杂志,2001,22(4):213-215. 被引量:42
  • 9吴晓娟,冯杰雄,魏明发,郭先娥,黎润光,宣晓琪.先天性巨结肠症术后小肠结肠炎发生与合并神经节细胞减少症的相关性分析[J].中华小儿外科杂志,2007,28(12):627-629. 被引量:7
  • 10Satoshi I,Mayumi H,Risa T. Clinical features of Hirschsprung's disease associated with Down syndrome:a 30-year retrospective nationwide survey in Japan[J].Journal of Pediatric Surgery,2009,(12):2347-2351. 被引量:1

二级参考文献18

共引文献45

同被引文献93

  • 1余世耀,施诚仁,励楚刚,王捍平,葛莉,许德棣,张驰.先天性巨结肠经肛门一期拖出术的评估[J].上海第二医科大学学报,2005,25(1):80-81. 被引量:8
  • 2Gunnarsdottir A,Wester T. Modern treatment of Hirschspr- ung's disease[J]. Scand J Surg, 2011,100(4) : 243-249. 被引量:1
  • 3Giuffrida P,Biancheri P,MacDonald TY. Proteases and small intestinal barrier function in health and disease [J]. Current Opinion in Gastroenterology, 2014,30( 2 ) : 147-153. 被引量:1
  • 4Mathur P, Mogra N, Surana SS, et al. Congenital segmental dilatation of the colon with anorectal malformation[J]. Jour- nal of Pediatric Surgery, 2004,39 (8) : e 18-20. 被引量:1
  • 5Pontarelli EM,Ford HR, Gayer CP. Recent developments in Hirschsprung's-associated enterocolitis[J]. Curr Gas- troenterol Rep, 2013,15 (8) : 340. 被引量:1
  • 6Giuliani S, Betalli P, Narciso A, et al. Outcome compari- son among laparoscopic Duhamel,laparotomic Duhamel, and transanal endorectal pull-through:A single-center, 18-year experience[J]. J Laparoendosc Adv Surg Tech A, 2011,21 (9) : 859-863. 被引量:1
  • 7Suzuki T, Won KJ, Horiguchi K, et al. Muscularis inflammation and the loss of interstitial ceils of Cajal in the endothelin ETB re- ceptor null rat [ J]. Am J Physiol astrointest Liver Physiol, 2004, 287(3) : G638 -646. 被引量:1
  • 8Alessio P P, Valerio G, Camilla G, et al. Hirschsprung's disease: 13 years'experience in 112 patients from a single in- stitu-fion[J]. Pediatr Surg Int, 2008, 24(2) : 175 -182. 被引量:1
  • 9Ruttenstock E, Puri P. Systematic review and meta-analysis of enterocolitis after one-stage transanal pull-through proce- dure for Hirschsprung's disease [ J]. Pediatr Surg Int, 2010, 26(11) : 1101 -1105. 被引量:1
  • 10Morty T L, Seo T, Matlak M E, et al. Gastrointestinal func-tion after surgical correction of Hirsehsprung's disease: long- term follow- up in 135 patients[ J]. J Pediatr Surg, 1995, 30(5) : 655 -658. 被引量:1

引证文献11

二级引证文献51

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部