摘要
目的探讨冠状动脉粥样硬化性心脏病（CAD）患者血清胱抑素C（CysC）水平与其病变严重程度的关系。方法对194例行冠状动脉造影检查患者，根据结果分为冠心病组（102例）和对照组（非冠心病组92例），利用乳胶免疫增强比浊法检测两组患者血清CysC水平并进行比较。同时将患者按血清CysC水平〈0．67mg／L、≥0．67mg／L、≥0．89mg／L和〉1．00mg／L分为四组，比较各组的临床资料，明确血清CysC水平与冠心病及冠脉血管病变严重程度的关系。结果冠心病组血清CysC水平明显高于对照组（P〈0．05），随着血清CysC水平的升高，冠心病患者病情逐渐加重，冠状动脉病变严重程度评分增加；Logistic回归结果显示CysC是CAD发生的独立危险因子，与CAD病变程度相关；ROC曲线分析显示，取血清CysC水平0．79mg／L为临界值，预测的CAD发生的灵敏度和特异性分别为76．60％和82．60％。结论CysC是预测CAD发生的有价值的临床指标，血清CysC水平与冠心病有密切关系，随着血清CysC水平升高，冠心病患者病情逐渐加重。
Objective To evaluate the relationship of serum cystatin C （Cys C） levels and the severity of coronary artery diseases （CAD）. Methods A total of 194 patients underwent coronary angiogra- phy were divided into two groups （102 CAD patients） and control group （non-CAD group, 92 cases） . To study the relationship of the level of serum cystatin C and the severity of CAD, the serum cystatin C of all enrolled patients was detected by immune-enhancing latex turbidimetry and the serum cystatin C level of CAD group was compared to control group. Results The serum levels of cystatin C of CAD were signifi- cantly higher than the control group （ P 〈 0.05）. With the increased levels of serum Cys C, CAD severity average score was increased; logistic regression analysis showed that Cys C was one of the risk factors of CAD. Cystatin C concentration was significantly correlated with CAD severity score. A cut-off value of 0.79 mg/L for cystatin C predicted incident CAD with a sensitivity of 76.60% and specificity of 82.60%, respectively. Conclusions Serum Cys C levels are valuable clinical predictors and closely related to CAD. With the increasing levels of serum Cys C, CAD becomes more severe.
出处
《中国医师杂志》
CAS
2012年第12期1609-1611,共3页
Journal of Chinese Physician
