摘要
目的探讨咪达唑仑复合舒芬太尼用于老年腰麻患者镇静时的最佳配伍剂量。方法选择80例腰麻下行下腹部或下肢手术患者,年龄≥65岁,ASA I~Ⅲ级,随机均分为4组：I组（S0.1,M10）,Ⅱ组（S0.1,M30）,Ⅲ组（S0.15,M20）,Ⅳ组（S0.2,M10）,单位均为μg/kg,每组20例。记录给药前（T0）、给药后5 min（T1）、10 min（T2）、30 min（T3）、60 min（T4）时警觉/镇静（OAA/S）评分,SBP、DBP、HR、RR、SpO2、警觉/镇静（OAA/S）评分、遗忘程度及不良反应。结果 4组患者的SBP、DBP、HR、SpO2在均在正常范围内有所降低。Ⅳ组在给药后5 min,10 min的SpO2明显低于其他3组（P〈0.05）,Ⅱ组给药后5 min,10 min的OAA/S评分低于I,Ⅲ,Ⅳ组（P〈0.05）,Ⅱ组的完全遗忘程度高达50%,明显高于I,Ⅲ,Ⅳ组（P〈0.05）。结论咪达唑仑30μg/kg复合舒芬太尼0.1μg/kg镇静遗忘效果好,且呼吸和循环抑制作用少,可作为老年患者理想的镇静配方。
【Objective】To observe the optimal dose of midazolam combined with sufentanil for sedation in elderly patients during spinal anesthesia.【Methods】80 ASA I-Ⅲ patients were randomly assigned into the following groups： group I（S0.1,M10）,groupⅡ（S0.1,M30）,group Ⅲ（S0.15,M20）,group Ⅳ（S0.2,M10）.OAA/S score,amnesia,hemodynamic and respiratory changes,the adverse reactions were recorded.【Results】SBP,DBP,HR,SpO2 of the 4 group decreased in normal range,SpO2 of group Ⅳ 5 min,10 min after receiving sedative was lower than that of the other groups（P〈0.05）;OAA/S score of group Ⅱ 5 min,10 min after receiving sedative was lower than that of the other groups（P〈0.05）;amnesia of group Ⅱ was 50%.【Conclusion】30μg/kg midazolam combined with 0.1μg/ kg sufentanil was the optimal dose for sedation in elderly patients during spinal anesthesia.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2012年第30期85-88,共4页
China Journal of Modern Medicine
