摘要
目的:评价人群心血管疾病对年龄相关性白内障(age-related cataract,ARC)发生的影响。方法:采用回顾性病例对照研究方法,2009-09/2011-03对360例病例和匹配的360例对照进行了调查。主要的测量指标为心血管疾病(cardiovascular disease,CVD)与ARC关联的比值比(OR)及其相应的95%可信区间(CI)。采用自行设计的调查表对研究对象进行调查。结果:病例组与对照组之间,年龄、职业,以及居住地的差异无统计学意义。调整了多种潜在性混杂因素后,空腹血糖受损的研究对象和已确诊的糖尿病患者发生ARC的危险性分别升高了62.4%和69.8%(OR=1.624,95%CI:1.068～2.553,P=0.007;OR=1.698,95%CI:1.412～2.719,P=0.009);高血压患者与ARC的关联性较强(OR=1.431,95%CI:1.098～1.997,P=0.007);现行吸烟者和现行饮酒者发生ARC的危险性也显著增高(OR=1.712,95%CI:1.312～2.344,P=0.010;OR=1.912,95%CI:1.310～2.896,P=0.003)。结论:糖尿病、高血压、吸烟及饮酒可使发生ARC的危险性增加,最终导致ARC的发生。
AIM：To evaluate the influence of cardiovascular disease on age-related cataract（ARC）.METHODS：A retrospective case-control study of all the cases（years 2009.09-2011.03）（n=360） and 360 matched controls.The main outcome measures were the odds ratios（OR） and corresponding 95% confidence intervals（CI） of ARC.All subjects were interviewed using a structured interviewer-administrated questionnaire.RESULTS：No difference was found in age,occupation,residence.After adjustment for multiple potential confounders,the risks of ARC for cases in fasting glucose impaired and diabetes increased 62.4% and 69.8%,respectively（OR=1.624,95% CI：1.068-2.553,P=0.007;OR =1.698,95% CI：1.412-2.719,P=0.009）.The risk of ARC in hypertension significantly increased（OR=1.431,95% CI：1.098-1.997,P=0.007）.Current smoking and drinking were risk factors of ARC（OR=1.712,95% CI：1.312-2.344,P=0.010;OR=1.912,95% CI：1.310-2.896,P=0.003）.CONCLUSION：Diabetes,hypertension,smoking,and drinking have higher risks of ARC,and eventually lead to the occurrence of ARC.
出处
《国际眼科杂志》
CAS
2013年第1期145-148,共4页
International Eye Science
基金
中国辽宁省教育厅科学技术研究基金资助项目(No.2008424)~~
