摘要
目的:考察痰热清注射液与常用输液及药物配伍后的变化。方法:观察痰热清注射液与常用输液和药物配伍后的pH值、药物性状变化,用高效液相色谱法测定黄岑苷、绿原酸的含量变化。结果:痰热清注射液与pH值大于7.8的药物输液如阿莫西林/舒巴坦钠、碳酸氢钠电解质、奥美拉唑、地塞米松磷酸钠注射液等混合后颜色变暗棕色,黄岑苷和绿原酸含量下降;与pH值低于4.7的药物输液如维生素B6、奥硝唑、头孢噻肟钠、头孢唑林钠、头孢硫脒、头孢哌酮/舒巴坦钠、盐酸溴己新葡萄糖注射液等混合后产生白色浑浊,绿原酸等成分含量下降。结论:痰热清注射液宜用0.9%氯化钠注射液稀释后静脉滴注,与其他药物联合静脉滴注时,两种药液间应使用0.9%氯化钠注射液冲管或分开注射。
Objective： To examine the compatibility of Tanreqing injection and its changes with other medicines.Methods： The changes of characters and pH were observed.The content of baicalin and chlorogenic acid were determined by HPLC method.Results： When Tanreqing injection were mixed with transfusions（pH7.8）,such as amoxicillin sodiumand/sulbactam sodium,dexamethasone sodium phosphate,sodium bicarbonate,omeprazole,it became dark brown,and the content of baicalin and chlorogenic acid declined.When it were mixed with transfusions（pH4.7） such as vitamin B6,ornidazole,cefotaxime sodium,cephazolin sodium,cefathiamidine,cefoperazone sodium/sulbactam sodium,it caused white turbidity,and the content of chlorogenic acid and other component declined.Conclusions： Tanreqing injection should be diluted by 0.9 % sodium chloride before intravenous injection.Combination of Tanreqing injection and other medicines for infusion should be applied through separate injection or flushed perfusion tube.
出处
《儿科药学杂志》
CAS
2013年第1期28-32,共5页
Journal of Pediatric Pharmacy
关键词
痰热清注射液
PH
黄岑苷
绿原酸
Tanreqing injection
pH
Baicalin
Chlorogenic acid
