摘要
目的 :研究 Ki- 6 7、PCNA、nm 2 3基因表达与膀胱移行细胞癌分级、分期及复发的关系 ,对预后作出估计。方法 :膀胱移行细胞癌石蜡包埋标本 44例 ,正常对照标本 8例。采用免疫组化 SABC法 ,对标本切片进行染色。结果 :Ki- 6 7/ MIB- 1在 G1 、G2 、G3各级别间及 p Ta+p T1 、p T2 、p T3各期别间差异显著 (P <0 .0 5 ) ;PCNA蛋白在 G1 +G2 和 G3间 ,p Ta+p T1 和 p T2 +PT3间差异显著 (P <0 .0 5 )。二者表达强度与膀胱癌分级、分期呈正相关性。高表达组的病人 ,膀胱癌复发率高于低表达组 (P <0 .0 5 )。 nm2 3在低分化和高期别的肿瘤组织中有表达减少的趋势。复发组与未复发组比较 ,nm2 3表达无差异性。结论 :Ki- 6 7和 PCNA的表达可作为膀胱肿瘤预后估计的指标 ,Ki- 6 7可能会更精确 ;nm2
Objective:We retrospectively reviewed 44 patients with bladder cancer to study whether the expression of Ki 67, PCNA ,and nm23 predicts recurrence and progression. Methods: The specimens of bladder cancer were immunostained with Ki 67, PCNA ,and nm23.Results: The recurrence rate , the stage, and the grade were significantly higher in patient with higher expression of Ki 67 , PCNA than those with low expression (P< 0.05). The recurrence rate in patients with moderate and high expression of Ki 67 is 75% (P<0.01) , and that of PCNA is 69.2% (P<0.05).There are less evidence in correlation between the recurrence rate ,the stage ,and the expression of nm23.Conclusion:Both of the Ki 67 and PCNA labeling index are predictive factor for recurrence of superficial bladder cancer, but the Ki 67 may be better than PCNA.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2000年第3期204-205,共2页
Journal of China Medical University
