摘要
C-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)家族是促分裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)超家族成员之一,也被称为应激活化蛋白激酶(stress-activated MAP kinase,SAPK)。JNK信号通路可被细胞因子、应激等多种因素激活,在细胞增殖与分化、细胞凋亡等多种细胞调控方面起着至关重要的作用。众多实验证实JNK与多种恶性肿瘤疾病有密切联系,JNK信号通路可作为多种恶性肿瘤的分子治疗靶点。
C-Jun N-terminal kinase（JNK）,also referred to as stress-activated kinase（SAPK）,constitute a subfamily of the mitogen-activated protein kinase（MAPK） superfamily.The JNK signal pathway can be activated by cytokines,stresses and so on.JNK plays important roles in cell regulation such as cell proliferation and differentiation,apoptosis and so on.Many studies have demonstrated that JNK pathway is closely associated with many malignant tumors.Components of the JNK signaling pathway represent potential molecular targets for the treatment of many malignant tumors.
出处
《实用中医内科杂志》
2012年第12期10-11,13,共3页
Journal of Practical Traditional Chinese Internal Medicine
基金
广东省自然科学基金资助项目(粤科基办字[2010]3号)
广东省高等学校高层次人才项目(粤教师函[2010]79号)
