摘要
肥胖是目前威胁全世界人民健康的重大公共卫生问题之一。近年来肥胖相关的肿瘤也成为一个人类主要的健康问题而受到广泛关注。对于肥胖相关肿瘤的危险性因子如胰岛素、胰岛素类生长因子、脂肪因子以及多个细胞内信号通路已有研究。本文综述肥胖引起的危险因子激活PI3K/Akt,MAPK及STAT3通路来促进肿瘤发生发展的分子机制,并对其进一步的研究与防治进行展望。
Recently, obesity has threatens the health of people as one of the major public health problems all over the world. In recent years, obesity-related tumors has become a major human health problem and drawn wide attention. Risk factors of obesity-related tumors, such as insulin, insulin-like growth factors, adipokines, as well as multiple intracellular signaling pathways have been studied. This article reviews the risk factors which activating PI3K/Akt, MAPK and STAT3 signal pathways because of obesity to promote the molecular mechanisms of tumorigenesis, and further research and prophylaxis and treatment.
出处
《内蒙古医学院学报》
2012年第6期505-511,共7页
Acta Academiae Medicinae Neimongol
基金
全国大学生创新训练计划项目(1110126012)
内蒙古自然基金(2010MS1123)
关键词
肥胖
癌症
信号通路
obesity
cancer
signaling pathway
