摘要
研究发现,MMR及MGMT蛋白表达缺失与大肠癌等恶性肿瘤的发生密切相关,胃癌及非小细胞肺癌常出现MMR和MGMT蛋白表达增高。本文通过介绍DNA修复系统中ERCC1、XRCC1和MMR、MGMT的作用机制及它们与肿瘤发生和化疗耐药性的关系,提出DNA修复系统关键蛋白的表达降低与肿瘤发生有关,在肿瘤发展过程中也会出现表达增高,且它们表达的增高或降低均与肿瘤化疗耐药性有关。
Some researchers reported that the deficiency of MMR and MGMT proteins was associated with colorectal cancer and other cancers,and proteins of MMR and MGMT were over-expression in gastric cancer and non-small-cell lung cancer.This article introduces the mechanism of ERCC1,XRCC1,MMR,MGMT and the relationship with tumorigenesis and resistance to chemotherapy,and then suggests that hypo-expression of DNA repair proteins is associated with tumorigenesis and over-expression of them also appears in the development of tumors,and the abnormal expression is associated with resistance to chemotherapy.
出处
《大连医科大学学报》
CAS
2012年第6期519-524,共6页
Journal of Dalian Medical University
基金
国家自然科学基金项目(81071805)
