摘要
目的探讨3.0T磁共振成像对视-隔发育不良诊断价值,旨在提高对SOD认识。方法收集本院经临床确诊8例视-隔发育不良患者,所有患者经历常规MRI及DTI扫描,将原始图像传至ADW4.4工作站上进行数据后处理,量化分析ADC值及FA值。结果全部患者均有透明膈缺如及不同程度视觉通路发育障碍,单纯性以透明膈发育部分缺如或完全缺如,双侧或单侧视神经萎缩、变细为主,双侧侧脑室额角呈典型"盒子状";复杂性常合并多种脑发育畸形,其中以胼胝体发育不全较为常见(<60%),DTI显示胼胝体纤维束稀少,ADC值、FA值减低。结论 SOD是一种罕见遗传发育基因缺陷疾病,根据临床表现,难以诊断,常规MRI及DTI能够一次性清晰、全面显示SOD病理改变,为临床诊断提供有效诊断依据。
Objective To discuss the diagnostic value of magnetic resonance imaging at 3.0T in Septo-optic Dysplasia （ SOD） so as to improve recognition for SOD. Methods Ten patients with SOD confirmed clinically were collected in this work. All paitents underwent routine MRI and diffusion tensor imaging （DTI） scanning. After the aechaeo-imageings were delivered to the workstation of ADW4.4, the data were processed and, then, the ADC value and FA value were ana- lyzed. Results All patients manifested complete absence of the septum pellucidum and different level pathways for vision with disorder. Simplex retinitis displayed partial absence of the sep turn pellucidum orcomplete absence of the septum pel- lucidu and, unilateral or bilateral optic nerve atrophy, thinningz, bilateral frontal angle of lateral ventricles showed ＂scatu- la＂ signs; complex type was often combined more development malformation in brain, and the amongagenesis of corpus callosum was common（~60 ~ ）, DTI manifested rare fiber bundle of the septum pellucidu and the ADC value and FA val- ue were decreased. Conclusion As SOD is a rare disorder that is attributed to genes defect, therefore, according to clinical manifestation, it is hard for the diagnosis of this disorder. The routine MRI and DTI scanning can sharply and overall show the pathological alterations of SOD, thereby providing valid evidence for for clinical diagnosis.
出处
《医学影像学杂志》
2012年第12期2001-2004,共4页
Journal of Medical Imaging
关键词
视-隔发育不良
弥散加权成像
弥散张量成像
磁共振成像
Septo-optic Dysplasia
Diffuse weighing imaging Diffusion tensor imaging
Magnetic resonance imaging
