摘要
目的探讨慢性乙型肝炎病毒基因型与干扰素疗效的关系.方法 62例慢性乙型肝炎患者随机分为治疗组和对照组.对照组的患者实施常规的肝保护治疗.治疗组患者则在常规的保肝治疗的基础上,进行500万U的干扰素α肌肉注射治疗.所有患者均进行乙型肝炎病毒的基因型测定,最后进行不同HBV基因型的干扰素α治疗效果比较研究.结果乙型肝炎病毒患者的不同基因型在干扰素α治疗效果方面差异有统计学意义(P<0.05).结论在慢性乙型肝炎的治疗中,乙型肝炎病毒基因型的测定对于干扰素α最终的治疗效果预判有一定价值.
Objective To explore chronic hepatitis B virus genotype and its relationship with the curative effect of interferon.Methods 62 patients were randomly divided into treatment group and control group.Patients in control group were given the conventional treatment of liver protection.Patients in the treatment group were given 5 million units of interferon-alpha intramuscular injection treatment,besides the conventional treatment.All patients received hepatitis B virus gene type determination,then the interferon-alpha therapy effect were compared between different HBV genotypes.Result The interferon-alpha therapy effect had statistically significantly difference between patients with hepatitis B virus genotype（P 0.05）.Conclusion In the treatment of chronic hepatitis B,determination of hepatitis B virus genotype has significance in predicting the final treatment effect of interferon-alpha.
出处
《昆明医科大学学报》
CAS
2012年第11期49-52,共4页
Journal of Kunming Medical University
基金
延安大学专项科研基金资助项目(YD2010-04)
延安大学医学院专项科研基金资助项目(YXY2012-07)
关键词
慢性乙型肝炎
病毒基因型
干扰素
疗效
Chronic hepatitis B
Virus genotype
Interferon
Curative effect
