摘要
目的探讨肺多形性癌(pleomorphic carcinoma,PC)的临床表现、手术方法及预后,以提高其诊断和治疗的有效性。方法回顾性分析四川大学华西医院自2006年1月至2011年8月期间收治7例肺多形性癌患者的临床资料,男5例,女2例,男女比例为2.5∶1.0;平均年龄58.85(43～69)岁。并使用PubMed检索系统,检索关键词为Pulmonary pleomorphic carcinoma surgery,复习2005～2011年报道有完整资料的8例患者的文献,其中男7例,女1例,男女比例7︰1;平均年龄70.25(51～79)岁。15例患者均行手术治疗并行系统淋巴结清扫术。结果本组资料平均发病年龄64.93(43～79)岁;15例患者中,男12例,女3例,男女比例为4∶1;主要症状多为咳嗽,痰中带血及咯血,胸痛;病理诊断均为多形性癌。本院7例患者中,梭形细胞癌伴鳞癌3例,梭形细胞癌伴腺癌2例,梭形细胞癌伴大细胞癌和腺癌2例;截至随访时有3例术后死亡,最长生存时间49个月,4例恢复良好。检索文献资料的8例患者中,梭形细胞癌伴鳞癌4例,梭形细胞癌伴腺癌1例,梭形细胞癌伴大细胞癌和鳞癌1例,梭形细胞癌伴腺癌和鳞癌2例;截至随访时有5例术后死亡,最长生存时间22个月,3例恢复良好。结论肺多形性癌极为少见,积极手术治疗可取得较好的疗效。
Objective To investigate clinical characteristics,surgical strategy and prognosis of pulmonary pleomorphic carcinoma,and improve the diagnostic and therapeutic level of pulmonary pleomorphic carcinoma.Methods We retrospectively analyzed clinical data of 7 patients with pulmonary pleomorphic carcinoma who underwent surgical resection from January 2006 to August 2011 in West China Hospital of Sichuan University.There were 5 male patients and 2 female patients with the male/female ratio of 2.5︰1.0 and the mean age of 58.85（43-69） years old.We also conducted a literature review through PubMed using pulmonary pleomorphic carcinoma and surgery as the key words,and 8 patients with integral clinical data from 2005 to 2011 were identified.There were 7 male patients and 1 female patient with the male/female ratio of 7︰1 and mean age of 70.25（51-79） years old.All the patients underwent surgical resection and systemic lymph node dissection.Results The mean age of this group was 64.93（43-79） years old.Among the 15 patients,there were 12 males and 3 females with the male/female ratio of 4︰1.The main symptoms were cough,blood in phlegm,hemoptysis and chest pain.Pathology diagnosis confirmed pleomorphic carcinoma in all the patients.Among the 7 patients of our hospital,there were 3 patients with spindle cell with squamous cell carcinoma,2 patients with spindle cell with adenocarcinoma,and 2 patients with spindle cell with large cell carcinoma and adenocarcinoma.During follow-up,3 patients died with the longest survival time of 49 months,and the other 4 patients were still alive.Among the 8 patients in the literature review,there were 4 patients with spindle cell with squamous cell carcinoma,1 patient with spindle cell with adenocarcinoma,1 patient with spindle cell with large cell carcinoma and squamous cell carcinoma,and 2 patients with spindle cell with adenocarcinoma and squamous cell carcinoma.During follow-up,5 patients died with the longest survival time of 22 months,and the other 3 patients were still al
出处
《中国胸心血管外科临床杂志》
CAS
2012年第6期634-637,共4页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
关键词
肺多形性癌
外科治疗
预后
Pulmonary pleomorphic carcinoma
Surgery
Prognosis
