摘要
目的观察阿司匹林、阿托伐他汀、青霉素联合治疗急性脑梗死的疗效及对高敏C反应蛋白(hs-CRP)及纤维蛋白原(Fib)含量的影响。方法将186例急性脑梗死患者随机分为两组,联合治疗组(97例)给予肠溶阿司匹林300mg/d、阿托伐他汀20mg/d口服,连服21d,青霉素4000000U/d加入0.9%氯化钠溶液250mL静脉点滴,连用7d;对照组(89例):给予肠溶阿司匹林300mg/d口服,连服21d。两组患者均允许使用抗高血压药物。于治疗前后分别进行神经功能缺损程度评分(评价临床疗效)、hs-CRP及Fib含量的检测及头颅CT检查。结果联合治疗组总有效率(94.85%)明显高于对照组(71.91%)(P<0.05),联合治疗组hs-CRP及Fib含量比治疗前显著下降(P<0.05)。联合治疗组与对照组治疗后头颅CT病灶缩小或密度改善分别为73例(75.26%)、39例(43.82%),差异有统计学意义(P<0.05)。结论阿司匹林、阿托伐他汀、青霉素联合治疗急性脑梗死的效果明显,可明显改善患者的神经功能缺损程度,使hs-CRP及Fib下降。
Objective To observe the curative effects of aspirin atrovasttion penicillin in the combination treatment of acute cerebral infarction and its influence on high sensitive C-reactive protein and fibrinogen content. Methods One hundred and eighty-six patients with acutecerebral infarction were randomly divided into two groups. 97 patients in combination treatment group were treated with 300 mg/d aspirin, 20 mg/d atrovasttion all treatment lasted for 21 days. 4 000 000 U/d penicillin injection plus 250 mL saline intravenously. All treatment lasted for 7 days. 89 patients in control group were given 300 mg/d aspirin all treatment lasted for 21 days. The score of neurological deficit was evaluated to assess the clinical efficiency, the changes of indexes of hs-C-reactive protein and fibrinogen content and skull CT in the two groups were observed before and after treatment. Results Total effective rate （94.85%） in the combination treatment group was signifcantly higher than that in the control group （71.91%） （P 0.05）. Compared with those before treatment, the indexes high sensitive C-reactive protein and fibrinogen of content in the combination treatment group decreased significantly after treatment （all P 0.05）. By the examination of CT, lesion diminution rates or density improve rates of the 2 groups were 73 cases （75.26%） and 39 cases （43.82%）, respectively （P 0.05）. Conclusion Aspirin atrovasttion penicillin combination treatment is an effective drug for the treatment of acute cerebral infarction and can improve the score of neurological deficitindexes and decrease hs-C-reactive protein and finrinogen content.
出处
《中国当代医药》
2012年第34期76-77,共2页
China Modern Medicine
基金
广东省深圳市龙岗区医疗卫生科技计划项目(YLL2010011)
关键词
急性脑梗死
阿司匹林
阿托伐他汀
青霉素
联合治疗
高敏C反应蛋白
纤维蛋白原
Acute cerebral infarction
Aspirin
Atrovasttion
Penicillin
Combination treatment
High sensitive C-reactive protein
Fibriongen
