摘要
目的观察急性冠状动脉综合征(ACS)患者住院期间甲状腺激素(TH)、心肌肌钙蛋白Ⅰ(cTnI)和B型钠尿肽(BNP)水平的变化,探讨其与主要不良心脏事件(MACE)发生的关系。方法随机选取ACS患者120例,按照病型分为ST段抬高型心肌梗死(STEMI)、非ST段抬高型心肌梗死(NSTEMI)和不稳定性心绞痛(UA)3个亚组;按照患者住院期间是否再次发生MACE分为发生组[MACE(+)]和未发生组[MACE(-)],分别观察TH、cTnI和BNP水平。结果 NSTEMI组和STEMI组总三碘甲状腺原氨酸(TT3)水平明显低于UA组(P<0.05、P<0.01);NSTEMI组游离三碘甲状腺原氨酸(FT3)水平明显低于STEMI组和UA组(P<0.05)。MACE(+)组TT3和FT3水平明显低于MACE(-)组(P<0.01)。STEMI组、NSTEMI组cTnI水平明显高于UA组(P<0.01),NSTEMI组高于STEMI组(P<0.05),但在MACE(+)和MACE(-)组之间差异无统计学意义(P>0.05)。促甲状腺激素(TSH)、总甲状腺素(TT4)、游离甲状腺素(FT4)和BNP水平在STEMI、NSTEMI和UA 3组间以及MACE(+)和MACE(-)组间差异均无统计学意义(P>0.05)。MACE(+)组cTnI、BNP阳性率与MACE(-)组比较差异无统计学意义(P>0.05)。结论 ACS患者住院期间出现低TT3和FT3水平易发生MACE;cTnI和BNP对ACS患者住院期间发生MACE无提示意义,有待于进一步研究和探讨。
Objective To observe the changes of serum levels of thyroid hormone （TH）, cardiac troponin I （cTnI） and B-type natriuretic peptide（BNP） levels in patients with acute coronary syndrome（ACS） during the hospitalization period, and to study the relationship with major adverse cardiovascular events（MACE）. Methods A total of 120 ACS patients were enrolled randomly and classified into 3 groups including ST-segment elevation acute myocardial infarction （STEMI）, non-ST-segment elevation acute myocardial infarction （NSTEMI） and unstable angina（UA） according to the styles of ACS. According to the patients whether occurred MACE or not during the hospitalization period, 2 groups including MACE（＋） and MACE（-） were classified. TH, cTnl and BNP levels were observed respectively. Results The levels of total triiodothyronine （ TT3 ） in NSTEMI group and STEMI group were significantly lower than that of UA group（ P 〈 0.05, P 〈 0.01 ）. The free triiodothyronine （ FT3 ） level in NSTEMI group was significantly lower than those in STEMI and UA groups（ P 〈 0.05 ）. The levels of T13 and FT3 in MACE（＋） group were significantly lower than those in MACE（-）group（P 〈0.01 ）. The levels of cTnI in STEMI and NSTEMI groops were higher than that in UA group （ P 〈 0.01 ）. The levels of cTnI in NSTEMI group were higher than those in STEMI group （ P 〈 0.05 ） , but no statistical significance was found between MACE（＋） and MACE （-） groups （ P 〉 0.05 ）. Thyroid stimulating hormone （ TSH）, total tetraiodothyronine （33＇4） and free tetraiodothyronine （FT4） and BNP levels had no statistical significance both in STEMI, NSTEMI and UA groups and in MACE（＋） and MACE （-） groups （P 〉 0.05 ）. The positive rates of cTnI and BNP had no statistical significance between MACE （＋） and MACE （-） groups （ P 〉 0.05 ）. Conclusions MACE occurs commonly in the ACS patients with low TT3 and FT3 levels during the hospitalization
出处
《检验医学》
CAS
2012年第12期1054-1057,共4页
Laboratory Medicine
