摘要
目的研究全相合异基因造血干细胞移植(allo-HSCT)术后间质性肺炎(IP)的临床特点及疗效评估。方法对我院自2004年1月～2012年2月行全相合allo-HSCT的119例患者进行研究。所有患者均使用抗病毒、抗细菌、抗真菌等药物预防IP。IP的突出特点是发热、干咳、低氧血症及肺部CT间质改变。及时治疗,甲强龙为主,经验性采用广谱抗细菌、抗病毒等药物,短期疗效不佳,则尽早抗真菌治疗。结果 119例患者中有15例发生IP,发生率为13%。其中,4例死亡,死亡率为27%。结论早期全面预防,IP发生率明显下降;密切观察,及早诊断,治疗重点突出并及早联合处理,疗效显著。
Objective To research clinical feature,and appraisal of curative effect of interstitial pneumonia （IP） after HLA all coincided hemopoietic stem cell transplantation （allo-HSCT）.Methods Carried out clinical study to 119 patients who had accepted HLA all coincided allo-HSCT from Jan 2004 to Feb 2012 in our hospital.All of them were used drugs to resist virus,bacterium,fungi for preventing IP.The main clinical situation were as follows：fever,dry cough,hyoxemia and interstitial alteration of bellows CT.Treat in time,methylprednisolone was the first important drug,and used broad-spectrum antibiotic and drugs for resisting virus in experience.If could not get curative effect in short period,used antimycotic drug as early as possible.Results 15 of 119 patients suffered from IP,incidence rate was 13%.4 IP patients died.The death rate was 27%.Conclusion To prevent early overall,incidence rate of IP to descend obviously.To observe intimately,diagnose at an early date,treat IP,focal point outstanding,unite drugs early,can get best curative effect.
出处
《中国现代医药杂志》
2012年第11期27-29,共3页
Modern Medicine Journal of China
关键词
造血干细胞移植
间质性肺炎
Hemopoietic stem cell transplantation Interstitial pneumonia
