摘要
目的探讨颈动脉粥样硬化(Carotid atherosclerosis,CAS)斑块形成的相关危险因素,为脑梗死的防治提供依据。方法选择2009年8月至2011年11月期间在我院住院的脑梗死患者100例,均经颈动脉超声检查,根据检查结果(即有无斑块形成)将患者分为斑块组(64例)和无斑块组(36例),检测所有患者三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、空腹血糖水平(FBG)、纤维蛋白原(FIB)浓度、高敏C反应蛋白(hs-CRP)、肌酐(Cr),同时记录患者既往是否有高血压、糖尿病、吸烟等病史。结果斑块组年龄、吸烟、高血压发病率、糖代谢异常发病率、TC、TG、LDL、FIB浓度、hs-CRP显著高于无斑块组(P<0.05),两组间性别、HDL、Cr比较差异无统计学意义(P>0.05)。结论颈动脉斑块形成是多种危险因素共同作用的结果,相关因素有年龄、吸烟、高血压、糖代谢异常和TC、TG、LDL、FIB、hs-CRP指标升高等。
Objective To investigate the risk factors related to the formation of the carotid ather- osclerotic plaque so as to prevent and treat the cerebral diseases. Methods 100 inpatients admit- ted to our hospital from August,2009 to November, 201i were analyzed. They were all exam- ined with the carotid color Doppler flow imaging, and were grouped as plaque group （n = 64） and non plaque group （n=36）. Measured were some possible risk factors including blood cho- lesterol （ TG ）, triglyceride （ TC ）, low density lipoprotein （ LDL）, high density lipoprotein （HDL） ,fibrinogen （FIB）, blood sugar, high sensitive C reactive protein（ hs-CRP）, creatinine （Cr） ;the history of past illness including hypertensive disease,diabetes and smoking were re- corded. Logistic regression model was applied in the screening of risk factors. Results The mean age,smoking , incidences of hypertension,abnormal glycometabolism, blood cholesterol （TG）, triglyceride（TC）, low density lipoprotein（LDL） ,fibrinogen （FIB）and high sensitive C reactive protein were higher in patients with carotid plaques than those in patients without ca- rotid plaques by single-factor analysis. There was no significant difference of sex, high density lipoprotein （HDL）and Creatinine（Cr）. Conclusion The formation of the carotid atherosclrotic plaque results from a number of factors. Age, smoking, incidences of hypertension, abnormal glycometabolism, blood cholesterol （ TG ）, triglyceride （ TC）, low density lipoprotein （ LDL）, fi- brinogen （FIB）and high sensitive C reactive protein are the related risk factors of carotid plaque.
出处
《湖北民族学院学报（医学版）》
2012年第4期33-35,共3页
Journal of Hubei Minzu University(Medical Edition)
