摘要
目的研究肺癌患者血清中血管内皮钙黏着蛋白(VE-cadherin)的含量与临床特征之间的关系,探讨肺癌患者血清VE-cadherin含量的临床意义。方法采用酶联免疫吸附分析法(ELISA)对32例未经治疗的初诊肺癌患者(肺癌组)和40例健康者(对照组)血清VE-cadherin水平进行检测。结果肺癌组患者血清VE-cadherin水平明显低于健康对照组,差异有统计学意义(P<0.01)。肺癌组患者血清VE-cadherin水平与原发肿瘤范围(肺癌TNM分期中的T)有关,差异有统计学意义(P<0.05);与性别、年龄、病理类型、淋巴结转移、远处转移不相关,差异无统计学意义(P>0.05)。结论肺癌患者血清VE-cadherin含量明显降低,VE-cadherin可作为肺癌的一个新的血清学诊断指标。
Objective To detect serum level of vascular endothelial-cadherin（VE-cadherin） in patients with lung cancer,investigate the connections between VE-cadherin and the clinical characteristics,and to explore the clinical significance of VE-cadherin.Methods Serum level of vascular endothelial cadherin were measured using ELISA in 32 untreated initially diagnosed lung cancer patients（the cancer group） and 40 healthy individuals（the control group）.Results The serum VE-cadherin levels in lung cancer patients were significantly lower than those in the healthy individuals（P0.001）.Serum VE-cadherin level was correlated with primary tumor range（the T range）（P0.05）,but unrelated to sex,age,pathology type,lymph node metastases,and distant metastases（P0.05）.Conclusion The serum VE-cadherin levels in lung cancer patients were significantly lower than those in the healthy individuals.VE-cadherin could act as a new serum diagnostic target of lung cancer.
出处
《重庆医学》
CAS
CSCD
北大核心
2012年第36期3812-3813,共2页
Chongqing medicine
基金
重庆市自然科学基金资助项目(CSTC2011jjA0433)
