摘要
目的:评价舍曲林合并小剂量喹硫平治疗难治性老年抑郁症的疗效及安全性。方法:将60例难治性老年抑郁症患者随机单盲分为2组,舍曲林合并喹硫平组(30例):给予舍曲林(50～200mg/d)治疗的同时合并应用喹硫平(25～200mg/d),实际完成试验者27例;舍曲林组(30例):单用舍曲林(50～200mg/d)治疗,实际完成试验者26例,2组持续治疗观察期为6周。于入组前、入组后第2、6周末应用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HA-MA)和用药物不良反应进行评定。结果:舍曲林合并喹硫平组总有效率为62.96%;舍曲林组的总有效率为26.92%,2组比较有统计学意义(P<0.05)。2组患者的药物不良反应均轻微,无统计学意义。结论:舍曲林合并小剂量喹硫平治疗老年难治性抑郁症的疗效优于单用舍曲林,安全性较好。
Objective：To evaluate the curative effects and safety of sertraline combined with small doses of quetiapine in the treatment of patients with refractory depression in the elderly.Methods：60 patients with refractory depression in the elderly were randomly divided into observation group（sertraline combined with quetiapine group） and control group（sertraline group）,and each group has 30 patients.Observation group among which 27 cases completed the test actually was treated with quetiapine combined with sertraline and control group among which 26 cases completed the test actually was treated with sertraline alone for 6 weeks.The curative effects and safety of patients were measured with HAMD,HAMA and adverse drug reaction when admission,after second weekend and after sixth weekend.Results：The total effective rate of sertraline combined with quetiapine group was 62.96% and that of sertraline group was 26.92%.The differences in curative effects between the two groups were statistically significant（P〈0.05）.The adverse drug reactions of the two groups were minor and there were not significantly statistical differences.Conclusion：The curative effects of sertraline combined with quetiapine in the treatment of patients with refractory depression in the elderly are apparently suoerior to that of sertraline alone,and the safty is better.
出处
《医学理论与实践》
2012年第24期2995-2996,2998,共3页
The Journal of Medical Theory and Practice
关键词
抑郁症
舍曲林
喹硫平
Depression
Sertraline
Quetiapine
