摘要
目的评价复发性流产与胰岛素抵抗的相关性。方法检索Medline数据库、Elsevier数据库、中国期刊全文数据库、中国生物医学文献数据库、万方数据库、Springerlink数据库、EMBASE数据库中1996年6月至2012年4月有关复发性流产与胰岛素抵抗相关性的病例对照研究。对纳入的研究进行质量评价，采用RevMan5．1软件进行荟萃分析。结果最终有7篇文献纳入本研究，病例组（为复发性流产患者）467例，对照组（为无不良妊娠史的妇女）413例，两组患者平均年龄、体质指数比较，差异均无统计学意义（P〉0．05）。荟萃分析结果显示，病例组空腹血糖水平与对照组比较，差异无统计学意义（WMD=2．27，95％CI为-1．11～5．65，P〉0．05）；空腹胰岛素水平病例组较对照组高2．05mU／L，两组比较，差异有统计学意义（WMD=2．05，95％CI为1．03～3．08，P〈0．01）；病例组胰岛素抵抗指数〉4．5患者较对照组多，两组比较，差异有统计学意义（OR=3．36，95％CI为1．72-6．57，P〈0．01）；病例组空腹血糖水平／胰岛素水平〈4．5的患者较对照组多，两组比较，差异有统计学意义（OR=3．37，95％CI为1．90-5．99，P〈0．01）。结论胰岛素抵抗与复发性流产具有相关性，胰岛素抵抗可能参与复发性流产的发生。
Objective To evaluate the association between recurrent miscarriages and insulin resistance. Methods The case-control studies on the association between recurrent spontaneous abortion and insulin resistance from June 1996 to April 2012 were collected from Medline, Elsevier, Chinese Journal Full- text Database, Chinese Biological Medicine Database, data base of Wanfang, Springer link and EMBASE. RevMan 5. 1 software was used for Meta analysis. Results According to the included criteria, 7 clinical trials were finally selected. Total 467 cases with recurrent pregnancy loss were enrolled in study group, while 413 women with no history of abnormal pregnancies were enrolled in control group. No significant difference was found in average age and body mass index between the two groups （ P 〉 0. 05 ）. Meta analysis results showed that the level of fasting glucose was no statistical difference between study group and control group （ WMD = 2. 27, 95% CI： - 1.11 to 5.65, P 〉 0. 05 ） ; fasting insulin level was higher 2. 05 mU/L in study group than that of in control group, the difference was statistically significant （ WMD = 2.05, 95 % CI： 1.03 to 3.08, P 〈 0.01 ）. Case number of study group on Homa-insulin resistance 〉 4.5 was more than that of control group （ OR = 3.36,95% CI： 1.72 to 6.57 ,P 〈 0. 01 ）. Case number of study group on glucose/insulin ratio 〈 4. 5 was more than that of the control group, statistical difference was found （ OR = 3.37,95% CI： 1.90 to 5.99, P 〈 0. 01 ） . Conclusion Insulin resistance is associated with the susceptibility to recurrent miscarriages, and it may contribute to the occurrence of recurrent miscarriages.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2012年第12期915-919,共5页
Chinese Journal of Obstetrics and Gynecology
基金
安徽省年度科研计划（10021303020）.
