摘要
目的 :探讨慢性阻塞性肺病 (chronic obstructive pulmonary disease,COPD)日间动脉血氧分压 (Pa O2 )、动脉血二氧化碳分压 (Pa CO2 )对夜间血氧的影响。方法 :监测 30例 COPD患者和 10例正常对照的夜间血氧水平 ,按 Pa O2 、Pa CO2 分组比较。结果 :(1) Pa O2 >8k Pa时 ,睡眠时平均动脉血氧饱和度 (MSa O2 )与日间动脉血氧饱和度(Sa O2 ) ,一秒率 (FEV1 % )、Pa CO2 均相关 (P均 <0 .0 5 ) ;Pa O2 ≤ 8k Pa时 ,MSa O2 仅与 Sa O2 相关 (P <0 .0 5 ) ;(2 ) Pa O2 >8k Pa时 ,日间 Pa CO2 >6 k Pa者睡眠时最低动脉血氧饱和度 (Min Sa O2 )与日间 Pa CO2 相关 (P <0 .0 5 ) ,日间 Pa CO2 ≤ 6 k Pa者 Min Sa O2 与日间 Pa O2 相关 (P <0 .0 5 )。结论 :COPD患者日间 Pa O2 决定睡眠时血氧平均水平 ,Pa CO2
Objective:Our purpose was to study the changes of nocturnal hypoxemia in different daytime PaO 2 and PaCO 2 in patients with chronic obstructive pulmonary disease (COPD). Methods:Thirty patients were divided into groups based on different PaO 2 and PaCO 2 levels. Nocturnal oxygen saturation were measured in patients and compared with those of 10 healthy subjects. Results:(1) In patients with PaO 2>8 kPa, nocturnal mean oxyhemoglobin saturation (MSaO 2) was respectively correlated with daytime SaO 2, FEV 1% and PaCO 2 (P<0.05). When PaO 2≤8 kPa, MSaO 2 only depended on daytime SaO 2 (r=0.77,P<0.05). (2) In terms of PaO 2>8 kPa, nocturnal minimum oxyhemoglobin saturation (MinSaO 2) with daytime PaCO 2>6 kPa was decided by daytime PaCO 2 (r=0.74, P<0.05) and that with daytime PaCO 2≤6 kPa was chiefly related to daytime PaO 2 (r=0.70, P<0.05). Conclusion:Daytime PaO 2 was the determinant of nocturnal mean oxygen level, and PaCO 2 was related to nocturnal minimum oxygen saturation.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2000年第1期39-41,共3页
Journal of China Medical University
