摘要
金纳米粒子与蛋白质间存在多种作用方式,包括物理吸附、化学共价结合以及非共价特异性吸附等.金纳米粒子表面等离子体共振效应引起可见光区的特征吸收及表面增强拉曼散射,常用来研究金纳米粒子与蛋白质间的相互作用.金纳米粒子与蛋白质间的作用与纳米粒子的尺寸、表面化学及蛋白质的大小、电荷、氨基酸残基有关.利用金纳米粒子与蛋白质的相互作用及纳米金的谱学性质,可以对疾病或环境污染进行简单、高效、低成本检测,也可用于疾病治疗.
Gold nanoparticles and proteins can interact via physical adsorption,chemically covalent conjugation,affinity adsorption and so on.The surface plasma resonance and surface-enhanced Raman scattering of gold nanoparticles are usually used to investigate the interaction between nanoparticles and protein.Factors such as the size and surface chemistry of gold nanoparticles,property of proteins and environment of the solution can influence these interactions.Gold nanoparticles are widely applied in the fields of highly effective and low-cost detections for disease and environmental pollutants,and play an important role in the disease therapy via the special physic-chemical properties of gold nanoparticles and the interactions between nanoparticles and proteins.
出处
《中国科学：化学》
CAS
CSCD
北大核心
2012年第12期1672-1682,共11页
SCIENTIA SINICA Chimica
基金
国家自然科学基金(51073045
21025520
90813032
20890023
21105018)
国家重点基础研究发展计划(973计划
2009CB930001
2011CB933201
2012AA030608)
中国科学院方向性项目(KJCX2-YW-M15)
中国博士后面上项目(023260191)的资助
