摘要
目的研究C反应蛋白(CRP)和降钙素原(PCT)对监护室患者合并感染的鉴别意义和对脓毒症患者预后的评估作用。方法收集我院急诊监护室患者102例,分为脓毒症和非脓毒症组,比较两组入院时CRP、PCT和急性生理和慢性健康状况(APACHE)Ⅱ评分的区别;比较脓毒症组中的死亡患者与存活患者第7 d的CRP和PCT与第1 d的差别。结果脓毒症组患者入院时CRP和PCT大于非脓毒症患者(P=0.001),APACHEⅡ评分无显著性差异(P>0.05);脓毒症死亡患者第7 d的CRP和PCT与第1 d比较无差异差别(P>0.05),脓毒症存活患者第7 d的CRP和PCT较第1 d明显下降(P=0.001)。结论 CRP和PCT可以鉴别监护室患者是否合并感染。动态监测CRP和PCT对预测脓毒症患者预后有重要的临床意义,CRP和PCT持续高水平提示预后不良。
Objective To study the differential significance of C reactive protein （CRP） and procalcitonin （PCT） on ICU patients with infection and to evaluate their prognosis effect on sepsis patients. Methods 102 patients were divided into septic and non-septic group, and their CRP, PCT level and acute physiology and chronic health conditions （APACHE） II score difference were compared between the two groups at admission. Besides, the differences of CRP and PCT level among the deceased and the survival in the septic group were compared at the first and seventh days. Results The CRP and PCT levels of the septic group were higher than those of the non-septic group at admission （P=0. 001）, but the scores of APACHE II had no significant difference between the two groups （P 〉 0.05 ）. The CRP and PCT levels of the deceased in the septic group showed no significant differences at the first and seventh days （ P 〉 0.05 ）, while the CRP and PCT levels of the survival in the septic group decreased obviously from the first day to the seventh day （ P = 0. 001 ）. Conclusion The CRP and PCT levels can identify whether the patients in ICU have other infections or not. Therefore, dynamic monitoring of CRP and PCT levels has an important clinical significance on the prognosis of patients with sepsis, and the persistent high levels of CRP and PCT indicate an unfavorable prognosis.
出处
《临床肺科杂志》
2013年第1期82-83,共2页
Journal of Clinical Pulmonary Medicine
