摘要
目的:研究YWHAE基因多态性与中国汉族人群帕金森病之间的相关性。方法:采用TaqMan检测法对中国汉族人群258例帕金森病患者和260名正常对照YWHAE的3个位点(rs34041110,rs3752826,rs2131431)进行关联分析T,并使用SHEsis软件进行单核苷酸多态性分析,比较病例组和对照组等位基因频率,基因型频率及单倍型的差异。结果:我们发现YWHAE的三个位点基因频率,基因型频率两组间差异不明显(P>0.05)。rs34041110与rs3752826的LD分析其D'值r2均较大(D'=0.978,r2=0.875)。但进一步对两位点的单倍型分析发现其各种组合均无统计学差异。结论:本研究结果提示YWHAE基因的三个位点与中国汉族人群帕金森病的发生不存在相关性。
Objective： To study the relationship between YWHAE gene and Parkinson＇s Disease （PD）. Methods： Use TaqMan technology to test 258 PD patients and 260 controls. 3 SNPs （rs34041110,rs3752826,rs2131431 ） of YWHAE gene were tested. The allele frequency, genotypic frequency and haplotype were tested between cases group and controls group. Results： There was no difference of allele frequency and genotypic frequency between the two groups （P〉0.05）. The D＇ and r^2 of rs34041110 and rs3752826 were large （D＇=0.978, r^2=0.875）. The haplotype of the two SNPs was negative. Conclusion： There was no significant association between rs34041110, rs3752826, rs2131431 and PD for Chinese Han population.
出处
《现代生物医学进展》
CAS
2012年第31期6038-6041,共4页
Progress in Modern Biomedicine
