摘要
目的:探讨多西他赛同步放化疗治疗中晚期食管癌的近期疗效和不良反应。方法:将50例中晚期食管癌患者随机分成两组,多西他赛周剂量化疗同步放疗组(A组)25例和单纯放疗组(B组)25例,两组放疗均采用常规分割照射剂量60～66Gy,A组:多西他赛35mg/m2每周1次,连续6周,B组:行单纯放疗。结果:A组和B组的近期有效率分别为76%和44%,同步放疗组明显优于单纯放疗组(P<0.05),主要不良反应为放射性食管炎、骨髓抑制及消化道反应,同步放疗组与单纯放疗组无明显差异(P>0.05)。结论:多西他赛联合放疗优于单纯放疗,且不良反应可耐受,可作为提高中晚期食管癌疗效的一种重要治疗手段。
Objective：To explore the short - term curative effects and toxicities of docetaxel chemotherapy plus radiotherapy in the treatment of mediumterm and terminal esophageal cancer. Methods： Fifty patients with medium - term and terminal esophageal cancer were randomly divided into two groups ：the group A（25 cases）and the group B（25 cases）. The two groups both adopted conventional fractionation with exposure dose of 60 - 66 Gy. The group A used docetaxel 35mg/m^2 once a week and lasted for 6 weeks. The group B used radiotherapy only. Results ： In the group A, The short - term curative effect rate was 76%. In the group B, the shortterm curative effect rate was 44%. The short -term curative effect rates were thus much better than those in radiotherapy only group （ P 〈 0.05 ）. The major sideeffects were radiation esophagitis, bone marrow suppression and gastrointestinal reaction, there was no significant differ-ence in the incidence rates of the two groups （ P 〉 0. 05 ）. Conclusion ： The short - term curative effect of weekly dose docetaxel chemotherapy combined with radiotherapy is good for the patients with medium - term and terminal esophageal cancer, and the toxicities can be tolerated. This is a important treatment of improving the curative effects of mediumterm and terminal esophageal cancer
关键词
食管癌
中晚期
多西他赛同步放化疗
esophageell cancer
mrdiumterm and teminal
docetaxel chmotherapy plus radiotherapy
