摘要
目的分析高频及低频重复经颅磁刺激（rTMS）分别对强直型及震颤型帕金森病（PD）的治疗作用及机理。方法69例PD患者各分别接受高频（5Hz）及低频（0．5Hz）rTMS治疗，采用UPDRS评分、运动功能试验及运动诱发电位检查等分别评价疗效。结果32例以强直为主要表现的一PD患者经高频rTMS治疗后UPDRS总分较治疗前均显著降低（均P〈0．01），运动功能试验明显改善（P〈0．01），运动诱发电位静息阈值明显改善（P〈0．01）；37例以震颤为主要表现的PD患者经低频rTMS治疗结束后UPDRS总分较治疗前均显著降低（均P〈0．01），运动功能试验明显改善（P〈0．01），运动诱发电位静息阈值明显改善（P〈0．01）。结论高频rTMS对PD强直型效果优于震颤型，而低频rTMS对震PD颤型效果优于强直型。
Objective To investigate the therapeutic effects of repeated transcranial magnetic stimulation （rTMS） at high and low frequency for the rigidity and tremors of Parkinson＇s disease （PD）. Methods Sixty-nine patients with PD received rTMS at 5 Hz or 0.5 Hz. The efficacy was assessed using the unified Parkinson＇s disease rating scale （UPDRS） , motor function tests and motor evoked potentials （MEPs）. Results Thirty-two patients with rigidity from PD received 5 Hz rTMS therapy, and their UPDRS total scores decreased significantly. Their motor function test results improved significantly and their MEP relaxed motor thresholds were significantly elevated. Thirty- seven patients with tremors from PD received 0.5 Hz rTMS therapy, and their UPDRS total scores were significantly decreased. Their motor function test results improved significantly and their MEP relaxed motor thresholds were signi- ficantly elevated. Conclusion High frequency rTMS may improve the symptoms of patients with PD rigidity and low frequency rTMS may improve the symptoms of patients with PD tremors.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2012年第12期907-910,共4页
Chinese Journal of Physical Medicine and Rehabilitation
关键词
帕金森病
经颅磁刺激
运动诱发电位
Parkinson＇s disease
Transcranial magnetic stimulation
Motor evoked potentials
