摘要
目的 探讨非何杰金淋巴瘤 (NHL)中 P1 6基因缺失情况及其与组织亚型和治疗的关系。方法 采用聚合酶链反应 -单链构象多态银染技术 (PCR- SSCP)检测 2 9例非何杰金淋巴瘤患者 P1 6基因的变化。结果 2 9例非何杰金淋巴瘤中 1 2例存在 P1 6基因缺失 ,总缺失率 41 .3% ;1 2例缺失中有 6例在两个疗程化疗后缺失消失 ;高度恶性淋巴瘤缺失率高。结论 P1 6基因缺失在 NHL发病中起一定作用 ,其发生率与组织亚型和治疗效果有关。
Objective To investigate the alteration of P16 gene mutation and its correlation with tissue subtype and effectiveness in non Hodgkin′s lymphoma (NHL).Methods A total of 29 human non Hodgkin′s lymphoma were examined for mutations in exon 2 by using PCR SSCP silver staining technique.Results Mutations were found in 12 out of 29 cases(41.3%) with non Hodgkin′s lymphoma .No deletion was found in any of the low grade NHL.The mutations of P16 gene disapperaed after treatment remission.Conclusion The mutation of P16 gene may be related with the occurrence, tissue subtype and effectiveness in NHL.
出处
《西安医科大学学报》
CAS
CSCD
2000年第3期229-230,共2页
Journal of Xi'an Medical University(Chinese)
基金
海南省自然科学基金!( No.3961 3)
