摘要
目的探讨聚桂醇经皮经门静脉胃冠静脉栓塞治疗食管胃底静脉曲张出血的临床疗效。方法 2008年4月至2010年12月收治60例食管胃底静脉重度曲张出血患者。将患者随机分成两组行经门静脉介入栓塞治疗,A组30例,采用聚桂醇作为栓塞剂;B组30例,采用鱼肝油酸钠作为栓塞剂。比较两组治疗6个月后出血复发率和食管静脉曲张度。结果栓塞后6个月,A组出血复发患者3例,复发率10.0%,B组10例,复发率33.3%,组间差异有统计学意义(χ2=4.81,P<0.05)。术后6个月复查胃镜,A组食管胃底静脉曲张轻～中度20例,重度10例,有效率66.7%;B组轻～中度12例,重度18例,有效率40.0%,组间差异有统计学意义(χ2=4.28,P<0.05)。不良反应A组3例,B组8例,组间差异有统计学意义(χ2=4.32,P<0.05)。结论聚桂醇经门静脉介入栓塞治疗食管胃底静脉出血具有确切的疗效。
Objective To evaluate the clinical effect of percutaneous transsplenic variceal embolization （PTVE） with Lauromacrogol via portal vein in treating esophageal and gastric fundus varicose bleeding. Methods A total of 60 patients with esophageal and gastric fundus varicose bleeding, who were admitted to the hospital during the period from April 2004 to December 2010, were enrolled in this study. The patients were randomly divided into two groups. Patients in group A （n = 30） received PTVE with Lauromacrogol as embolic agent, while group B （n = 30） received PTVE with sodium morrhuate as embolic agent. The incidence of recurrent bleeding and the severity of esophageal varicose at 6 months after the treatment were determined. The results were compared between the two groups. Results Six months after the embolization, recurrent bleeding occurred in 3 patients of group A （10.0%） and in 9 patients of group B （30.0%）. The difference between the two groups was statistically significant （X2 = 4.81, P〈 0.05）. Gastroscopy examination showed that in group A mild- moderate degree of esophageal and gastric fundus varicose was seen in 20 patients, while severe degree of esophageal and gastric fundus varicose was seen in 10 patients. The effective rate was 66.7%. In group B mild-moderate degree of esophageal and gastric fundus varicose was seen in 12 patients, while severe degree of esophageal and gastric fundus varicose was seen in 18 patients. The effective rate was 33.3%. The difference between the two groups was statistically significant （X2 = 4.28, P 〈 0.05）. Adverse effect was seen in 3 patients of group A and 8 patients of group B. The difference between the two groups was statistically significant （X2 = 4.32, P 〈 0.05）. Conclusion For the treatment of esophageal and gastric fundus varicose bleeding, percutaneous transsplenic variceal embolization with Lauromacrogol via portal vein has reliable effectiveness.
出处
《介入放射学杂志》
CSCD
北大核心
2012年第12期995-997,共3页
Journal of Interventional Radiology
关键词
食管胃底静脉曲张
聚桂醇
门静脉介入
esophageal and gastricfundus varicose
Lauromacrogol
portal veinintervention
